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2-Methyl-2-phenyl-1,3-oxathiolane is a heterocyclic organic compound characterized by a six-membered ring containing one sulfur atom and one oxygen atom, with a methyl group and a phenyl group attached to the carbon atoms adjacent to the sulfur. 2-methyl-2-phenyl-1,3-oxathiolane is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly those containing the 1,3-oxathiolane ring system. It can be synthesized through various methods, such as the reaction of phenylacetaldehyde with ethanethiol in the presence of a catalyst. Due to its unique structure and reactivity, 2-methyl-2-phenyl-1,3-oxathiolane has potential applications in the development of new drugs and other chemical products.

5684-32-2

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5684-32-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5684-32-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,8 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5684-32:
(6*5)+(5*6)+(4*8)+(3*4)+(2*3)+(1*2)=112
112 % 10 = 2
So 5684-32-2 is a valid CAS Registry Number.

5684-32-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-methyl-2-phenyl-1,3-oxathiolane

1.2 Other means of identification

Product number -
Other names 1,3-Oxathiolane,2-methyl-2-phenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5684-32-2 SDS

5684-32-2Relevant academic research and scientific papers

Blue LED-Promoted Oxathiacetalization of Aldehydes and Ketones

Liu, You-Chen,Reddy, Daggula Mallikarjuna,Chen, Xin-An,Shieh, Yi-Chen,Lee, Chin-Fa

, p. 2542 - 2552 (2020/04/27)

In synthetic chemistry, the protection of aldehydes and ketones is crucial during multistep synthesis of complex molecules. Organic chemists have paid substantial attention to the synthesis of 1,3-oxathiolanes and 1,3-oxathianes because of their considera

Selective arylthiolane deprotection by singlet oxygen: A promising tool for sensors and prodrugs

Lamb, Brian M.,Barbas, Carlos F.

supporting information, p. 3196 - 3199 (2015/05/27)

A routine thioketal protecting group reacts rapidly and selectively with singlet oxygen to reveal ketone products in good (aryl 1,3-dithiolane) to excellent (aryl 1,3-oxathiolane) yields. Arylthiolanes are stable to biologically relevant reactive oxygen species and can be used as a light-activated gating mechanism for activating fluorescent sensors or small molecule prodrugs.

Facile protection of carbonyl compounds as oxathiolanes and thioacetals promoted by PEG1000-based dicationic acidic ionic liquid as chemoselective and recyclable catalyst

Ren, Yi-Ming,Shao, Juan-Juan,Wu, Zhi-Chuan,Zhang, Shuai,Tao, Ting-Xian

, p. 392 - 394 (2014/06/09)

Efficient oxathioacetalization and thioacetalization of carbonyl compounds have been achieved in high yields employing PEG1000-based dicationic acidic ionic liquid as a catalyst. The PEG ionic liquid and toluene have the advantages of both homo

Silica-gel supported sulfamic acid (SA/SiO2) as an efficient and reusable catalyst for conversion of ketones into oxathioacetals and dithioacetals

Aoyama, Tadashi,Suzuki, Toshihiko,Nagaoka, Takashi,Takido, Toshio,Kodomari, Mitsuo

, p. 553 - 566 (2013/01/15)

A simple and efficient method for the conversion of carbonyl compounds to oxathioacetals and dithioacetals using SA/SiO2 as an acid catalyst has been achieved. SA/SiO2 is easily recovered from the reaction mixture and can be reused at least 15 times without loss of catalytic activity.

An efficient method for the oxathioacetalization of carbonyl compounds using N-bromosaccharin as a catalyst

Alinezhad, Heshmatollah,Fallahi, Shahrouz

experimental part, p. 927 - 929 (2012/08/28)

A mild and highly chemoselective method for the preparation of oxathiolane from aliphatic and aromatic aldehydes and ketones with 2-mercaptoethanol in the presence of catalytic amount of N-bromosaccharin at room temperature is reported.

Catalytic carbon-sulfur bond formation by amphoteric vanadyl triflate: exploring with thia-Michael addition, thioacetalization, and transthioacetalization reactions

Chen, Chien-Tien,Lin, Yow-Dzer,Liu, Cheng-Yuan

supporting information; experimental part, p. 10470 - 10476 (2010/02/28)

A series of thiols have been examined as protic nucleophiles for Michael-type additions to α,β-unsaturated carbonyls as well as double nucleophilic condensations with aldehydes, ketones, and acetals catalyzed by amphoteric, water-tolerant vanadyl triflate under mild and neutral conditions. The newly developed C-S bond formation protocols were carried out smoothly in good to high yields in a highly chemoselective manner.

An efficient and mild deprotection of 1,3-oxathiolanes to carbonyl compounds using the superoxide ion

Singh, Satish Kumar,Singh, Krishna Nand

body text, p. 2339 - 2343 (2010/03/26)

An efficient deprotection of 1,3-oxathiolanes to carbonyl compounds has been achieved under the mild reaction conditions of tetraethylammonium superoxide in an aprotic medium at room temperature.

Facile protection of carbonyl compounds as oxathiolanes and transoxathioacetalization of oxyacetals promoted by iron(III) trifluoroacetate or trifluoromethanesulfonate as chemoselective and recyclable catalysts

Adibi, Hadi,Jafari, Hadi

, p. 679 - 682 (2008/01/01)

Oxathioacetalization of carbonyl compounds and transoxathioacetalization of O,O-acetals/ketals are reported under nearly neutral conditions promoted by iron(III) trifluoroacetate [Fe(CF3CO2)3] or trifluoromethanesulfonate

An efficient and chemoselective method for conversion of carbonyl compounds to 1,3-oxathiolanes with 2-mercaptoethanol catalyzed by TiCl 4-montmorillonite

Jin, Tong-Shou,Zhao, Rui-Qiao,Ma, Yan-Ran,Yang, Mi-Na,Guo, Jun-Jie,Li, Tong-Shuang

, p. 503 - 505 (2007/10/03)

Formation of 1,3-oxathiolanes from aldehydes and ketones using 2-mercaptoethanol in the presence of TiCl4-montmorillonite under mild reaction conditions in excellent yields is described. Chemoselective monothioacetalization of aldehyde in the p

Microwave-mediated efficient protection of carbonyl compounds as 1,3-oxathiolanes in the presence of iodine under solvent free condition

Bez, Ghanashyam,Baruah, Nabajyoti

, p. 542 - 543 (2007/10/03)

A mild, efficient, and solvent free protocol for conversion of aldehydes and ketones into their corresponding 1,3-oxathiolanes using 2-mercaptoethanol in the presence of catalytic amount of elemental iodine is reported. Copyright

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