41808-37-1

Basic information

• Product Name: 4-Isothiazolecarbonitrile, 5-amino-3-(1-methylethyl)-
• Synonyms: 5-Amino-4-cyano-3-isopropylisothiazol;5-amino-4-cyano-3-isopropylisothiazole;5-Amino-3-isopropyl-isothiazole-4-carbonitrile
• CAS NO: 41808-37-1
• Molecular Formula: C7H9N3S
• Molecular Weight: 167.235
• Mol File: 41808-37-1.mol

Chemical Properties

• Melting Point: 133 - 136 °C
• CAS DataBase Reference: 4-Isothiazolecarbonitrile, 5-amino-3-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isothiazolecarbonitrile, 5-amino-3-(1-methylethyl)-(41808-37-1)
• EPA Substance Registry System: 4-Isothiazolecarbonitrile, 5-amino-3-(1-methylethyl)-(41808-37-1)

Safety Data

• Hazardous Substances Data: 41808-37-1(Hazardous Substances Data)

Upstream product

• 41808-32-6 3-Amino-2-cyano-4-methyl-2-pententhiocarboxamid 
• 40797-97-5 (1-chloro-2-methylpropylidene)methane-1,1-dicarbonitrile 
• 40798-08-1 (1-hydroxy-2-methylpropylidene)methane-1,1-dicarbonitrile 
• 41808-27-9 2-amino-1,1-dicyano-3-methylbut-1-ene 

Relevant articles and documents

ISOTHIAZOLO[5,4-D]PYRIMIDINE COMPOUND AS IRAK4 INHIBITOR

Disclosed in the present invention are an IRAK4 inhibitor, and an application thereof in preparation of a drug for treating IRAK4-related diseases. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.

N,N-dialkyl-N'-(substituted-5-isothioazolyl)-N'-acylureas as herbicides

A new class of herbicidal compounds consisting of N,N-dialkyl-N'-(substituted-5-isothiazolyl)-N'-acylureas in which the 3-substitutent on the isothioazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, alkoxycarbonyl, and nitro; and in which the nitrogen atom of the N,N-dialkylurea to which the isothiazolyl moiety is bonded, is also bonded to an acyl moiety, exhibits outstanding preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail and the utility of representative compounds is exemplified.

Isothiazolylformamidine derivatives as herbicides

A new class of herbicidal compounds consisting of N'-(substituted-5-isothiazolyl)-N,N-dimethylformamidines in which the 3-substituent on the isothiazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, carbamoyl, and nitro, and in which the hydrogen of the dimethylformamidine moiety may be substituted by fluorine, chlorine, bromine, or carbonitrile, exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail, and the utility of representative compounds is exemplified.