41819-49-2Relevant academic research and scientific papers
Convenient access to 2-arylpyrroles from 2-lithio-N,N- dibenzylcyclopropylamine and nitriles
Tanguy, Chloé,Bertus, Philippe,Szymoniak, Jan,Larionov, Oleg V.,De Meijere, Armin
, p. 2339 - 2341 (2007/10/03)
N,N-Dibenzylaminocyclopropyl ketimines formed as intermediates upon treatment of 2-lithiated N,N-dibenzylcyclopropylamines with nitriles, being donor-acceptor-substituted cyclopropanes, immediately underwent ring-enlarging rearrangement and 1,2-elimination of dibenzylamine to produce 2-substituted pyrroles in good yields (14 examples, 55-80%). Georg Thieme Verlag Stuttgart.
Gold(I)-catalyzed intramolecular acetylenic Schmidt reaction
Gorin, David J.,Davis, Nicole R.,Toste, F. Dean
, p. 11260 - 11261 (2007/10/03)
Substituted pyrroles were prepared by a gold(I)-catalyzed acetylenic Schmidt reaction of homopropargyl azides. The reaction allows for regiospecific substitution at each position of the pyrrole ring under mild conditions. A mechanism in which azides serve as nucleophiles toward gold(I)-activated alkynes with subsequent gold(I)-aided expulsion of dinitrogen is proposed. Copyright
NEW METHODS FOR THE SYNTHESIS OF 2-ARYLPYRROLES
Kruse, Chris G.,Bouw, Jan P.,Hes, Roelof van,Kuilen, Aalt van de,Hartog, Jack A. J. den
, p. 3141 - 3151 (2007/10/02)
Two short and efficient synthetic approaches for -mostly unknown- 2-arylpyrroles are presented.The key intermediates 3 are conveniently obtained from commercially available acetophenones 5 (method I) or benzoic acid derivatives 10, 11 (method II).
