41828-91-5Relevant academic research and scientific papers
SYNTHESIS AND PHARMACODYNAMIC INVESTIGATION OF NEW ISOGUVACINE ANALOGUES WITH BENZOQUINOLIZINE SKELETON
Blasko, Gabor,Kardos, Julianna,Baitz-Gacs, Eszter,Simonyi, Miklos,Szantay, Csaba
, p. 2887 - 2900 (2007/10/02)
Stereoisomer hydroxy-esters 15 - 19 as well as isoguvacine analogue 20 with benzoquinolizine skeleton have been prepared via regioselective Dieckmann condensation of diester 9 followed by subsequent reduction and E2-elimination.Compounds 16 and 20 have shown a considerable in vitro activity at the GABA/benzodiazepine receptor complex.
