41841-02-5

Upstream product

• 37975-18-1 1-(4-bromophenyl)-3-(4-methoxyphenyl)propane-1,3-dione 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 67205-73-6 2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone 
• 5467-74-3 4-Bromophenylboronic acid 
• 1076-95-5 p-methoxyphenylglyoxal 
• 123-11-5 4-methoxy-benzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 30390-78-4 1-(4-bromophenyl)-2-(4-methoxyphenyl)ethan-1-one 

Relevant academic research and scientific papers

Copper-catalyzed TEMPO oxidative cleavage of 1,3-diketones and β-keto esters for the synthesis of 1,2-diketones and α-keto esters

A copper-catalyzed efficient and practical method has been developed for the synthesis of 1,2-diketones and α-keto esters. TEMPO was used as a radical initiator and scavenger, oxidizing the cleavage of α-methylene of 1,3-diketones and β-keto esters to form 1,2-diketones and α-keto esters. This method provided a general way for the formation of 1,2-dicarbonyl compounds.

Preparation method of 1,2-diketone derivative

The invention discloses a preparation method of a 1,2-diketone derivative. The method comprises the step of enabling a raw material 1,3-diketone derivative to react with a cheap and easily obtained industrial product 2,2,6,6-tetramethyl-1-piperidinyloxy under the catalysis of copper so as to obtain the product 1,2-diketone derivative. According to the preparation method, the 1,3-diketone derivative is used as an initiator, and the raw material is easy to obtain and wide in variety; by utilizing the preparation method, the obtained product types are varied, can be directly used, and can be used for other further reactions; in addition, the reagent dosage in the reaction is less, the pollution is reduced, and the production cost is lowered; moreover the reaction conditions are mild, the reaction operation and the after-treatment process are simple, the reaction time is short, the yield is high, and the preparation method is suitable for industrial production.

Copper-catalyzed base-accelerated direct oxidation of C-H bond to synthesize benzils, isatins, and quinoxalines with molecular oxygen as terminal oxidant

We describe herein an efficient and general copper (II)-catalyzed base-accelerated oxidation of the C-H bond to synthesize benzils and isatins. With similar oxidation system an efficient one-pot procedure for the synthesis of quinoxaline derivatives was realized. The two protocols feature using molecular oxygen as terminal oxidant, low catalyst loading, wide substrate scope, and high functional-group tolerance.

Aminocatalytic cross-coupling approach via iminium ions to different C-C bonds

Given the attractive ability of iminium ions to functionalize molecules directly at ostensibly unreactive positions, the reactivity of iminium ions, in which an α CH2 group is replaced by C=O was explored. Background studies on the ability of such iminium cations to promote reactions via an iminium-catalyzed or iminium-equivalent pathway are apparently unavailable. Previously, tandem cross-coupling reactions were reported, in which an iminium ion undergoes nucleophilic 1,2-addition to give a putative three-component intermediate that abstracts a proton in situ and undergoes self-deamination followed by unprecedented DMSO/ aerobic oxidation to generate a-ketoamides. However, later it was observed that iminium ions can generate valuable α-ketoamides through simple aerobic oxidation. In all reactions, iminium ions were generated in situ by reaction of 2-oxoaldehydes with secondary amines.

From enolates to anthraquinones

A series of highly reactive cyclopentadienones were prepared in situ from the corresponding hydroxycyclopent-2-enones and trapped with a variety of quinones. Reaction of 1,4-naphthoquinone with 4-hydroxy-3,4-diphenyl-cyclopent- 2-enone afforded 2,3-diphenylanthraquinone, whereas reaction of benzoquinone with this same cyclopentadienone precursor yielded a mixture of 6,7-dipheny 1-1,4-naphthoquinone and 2,3,6,7-tetraphenylanthraquinone. A number of other 2,3-diarylanthraquinones were likewise prepared in moderate yields from the reaction of 1,4-naphthoquinone with the appropriate 4-hydroxy-3,4- diarylcyclopent-2-enones. This method appears to be generally applicable to the synthesis of anthraquinone derivatives substituted at the 2- and 3-positions from inexpensive starting materials.