41841-87-6Relevant academic research and scientific papers
Synthesis, characterization, lipophilicity and cytotoxic properties of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes
Hizal, Selin,Hejl, Michaela,Jakupec, Michael A.,Galanski, Markus,Keppler, Bernhard K.
, p. 76 - 83 (2019/04/05)
A series of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes as well as an ethylamine analog were synthesized. The compounds are either symmetrical with both axial ligands consisting of monoesters of succinic acid, or unsymmetrical, with one axial ligand being acetate. The compounds were characterized in detail by elemental analysis, mass spectrometry and multinuclear (1H, 13C, 15N, 195Pt) NMR spectroscopy. The reduction behavior was followed by NMR spectroscopy, while lipophilicity was determined by analytical reversed-phase HPLC measurements. The capacity of inhibiting proliferation of the human cancer cell lines A549 (non-small cell lung cancer), CH1(PA-1) (ovarian teratocarcinoma) and SW480 (colon carcinoma) was evaluated by the MTT assay. In the most sensitive cell line CH1(PA-1), all compounds exhibited IC50 values in the lower μM range. In general, the IC50 values decreased with increasing lipophilicity within the two compound series. Nevertheless, replacing one of the succinic ester ligands with acetate has a rather marginal impact on antiproliferative activity and is hardly disadvantageous.
Synthesis and characterization of Pt(II) complexes with amine and carboxylato ligands. Crystal structure of (1,1-cyclobutanedicarboxylato)di(ethylamine)platinum(II)·H2O
Rochon, Fernande D.,Gruia, Letitia M.
, p. 193 - 204 (2008/10/08)
Two methods for the synthesis of compounds of the type cis-PtA2X2 (A2 = bidentate amine or two monodentate amines and X2 = bidentate or two monodentate carboxylato ligands) were evaluated. The compounds were characterized by multinuclear NMR and IR spectroscopies. The 195PT NMR chemical shifts were in the range - 1615 to - 1976 ppm, the higher field values corresponding to the complexes containing bidentate ligands. The coupling constants 3J(195Pt-1H) are approximately 35 Hz, while the 2J(195Pt-1HN) are about 70 Hz. One coupling constant 2J(195Pt-13C) (53 Hz) was also measured. The crystal structure of the compound, cis-Pt(1,1-cyclobutanedicarboxylato)(C2H5NH2)2·H2O belongs to the P21/n space group with a=9.468(5), b =9.365(4), c = 16.473(7) A?, β = 105.08(3)°, Z = 4 and R1 = 0.0576. The Pt-N bond distances are 1.992(5) and 2.020(5) A?, while the Pt-O bonds are 2.000(4) and 2.015(4) A?. The molecules are held together by intermolecular H-bonds involving the lattice water molecules and the two free carbonyl O atoms and between the amino H atoms and the Pt-bonded C-O groups. (C) 2000 Elsevier Science S.A.
