41846-01-9

Upstream product

• 628-71-7 1-Heptyne 
• 108-91-8 cyclohexylamine 
• 106-30-9 ethyl heptanoate 
• 111-14-8 oenanthic acid 
• 70584-30-4 N-cyclohexyl-3,5-dimethyl-1H-pyrazole-1-carboxamide 
• 111-71-7 heptanal 
• 106-73-0 methyl heptanoate 
• 1340546-37-3 1-heptanoyl-1,2-hydrazinedicarboxylic acid 1,2-diisopropyl ester 

Relevant academic research and scientific papers

One-Pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes

A mild, one-pot, and environmentally friendly synthesis of amides from aldehydes and amines is described. Initially, a photoorganocatalytic reaction of aldehydes with di-isopropyl azodicarboxylate leads to an intermediate carbonyl imide, which can react with a variety of amines to afford the desired amides. The initial visible light-mediated activation of a variety of monosubstituted or disubstituted aldehydes is usually fast, occurring in a few hours. Following the photocatalytic reaction, addition of the primary amine at room temperature or the secondary amine at elevated temperatures leads to the corresponding amide from moderate to excellent yields without epimerization. This methodology was applied in the synthesis of Moclobemide, a drug against depression and social anxiety.

Radical mediated-direct conversion of aldehydes into acid bromides

A method of preparing acid bromides directly from aldehydes with Br3CCO2Et under radical conditions was developed. Aromatic aldehydes with electron-donating group were found to be more reactive than aromatic aldehydes with electron-w

Tighter ion pair effect and scale-up study in microwave assisted aminolysis of enolizable esters using potassium tert-butoxide (t-BuOK)

The tighter ion pair effect and scale-up study in aminolysis of enolizable esters using potassium tert-butoxide (t-BuOK) under microwave irradiations is described. This method provides synthetic advantages in terms of reaction time, product yields, eco-friendly environment and scale-up feasibility over the conventional heating method.

A catalyst system for the formation of amides by reaction of carboxylic acids with blocked isocyanates

A catalyst for the reaction of blocked isocyanates (blocking agent diisopropylamine and dimethyl pyrazole) and carboxylic acids was identified. Magnesium and in some instances calcium salts proved to be highly active as catalyst. This reaction gives amides in quantitative yield and excellent selectivity and is suitable for coating and general chemical purposes.