70584-30-4Relevant articles and documents
Rhodium(III)-catalyzed Intermolecular Unactivated Secondary C(sp3)?H Bond Amidation Directed by 3,5-dimethylpyrazole
Wang, Yanwei,Liu, Hongxin,Li, Bin,Wang, Baiquan
, p. 1564 - 1569 (2019)
A Rh(III)-catalyzed intermolecular unactivated secondary C(sp3)?H bond amidation via nitrene insertion directed by 3,5-dimethylpyrazole is reported. This procedure tolerates a broad substrate scope including chain and cyclic N-alklyamides. Notably, the directing group 3,5-dimethylpyrazole of chain N-alkylamide substrates could be easily removed via cascade intermolecular amidation and intramolecular cyclization in one-pot affording the sulfonylureas by increasing the reaction temperature. (Figure presented.).