41855-53-2Relevant academic research and scientific papers
Synthesis of Kr?hnke pyridines through iron-catalyzed oxidative condensation/double alkynylation/amination cascade strategy
Gopalaiah, Kovuru,Choudhary, Renu
supporting information, (2021/09/15)
An efficient protocol for the synthesis of symmetrical and unsymmetrical 2,4,6-trisubstituted pyridines via oxidative cascade annulation of arylacetylenes with benzylamines has been developed. The reaction proceeds smoothly utilizing iron(II) triflate as a catalyst and molecular oxygen as an oxidant with broad substrate scope. Mechanistic studies reveal that the reaction may be experiences an oxidative condensation followed by double alkynylation and amination process.
HOTf-catalyzed sustainable one-pot synthesis of benzene and pyridine derivatives under solvent-free conditions
Zhang, Xu,Wang, Zhiqiang,Xu, Kun,Feng, Yuquan,Zhao, Wei,Xu, Xuefeng,Yan, Yanlei,Yi, Wei
supporting information, p. 2313 - 2316 (2016/05/19)
Herein a versatile HOTf-catalyzed and solvent-free system for highly efficient one-pot synthesis of privileged benzene and pyridine derivatives has been developed using ketones and ketones with amines as simple substrates, respectively. The remarkable features of this "green" reaction include good to excellent yields, exclusive chemoselectivity and broad substrate/functional group tolerance.
Molecular Iodine-Mediated Chemoselective Synthesis of Multisubstituted Pyridines through Catabolism and Reconstruction Behavior of Natural Amino Acids
Xiang, Jia-Chen,Wang, Miao,Cheng, Yan,Wu, An-Xin
supporting information, p. 24 - 27 (2016/01/15)
A new process has been developed for the selective construction of 2,6-disubstituted, 2,4,6-trisubstituted, and 3,5-disubstituted pyridines based on the catabolism and reconstruction behaviors of amino acids. Molecular iodine was used as a tandem catalyst to trigger the decarboxylation-deamination of amino acids and to promote the subsequent formation of the pyridine products.
Synthesis of multisubstituted pyridines
He, Zhi,Dobrovolsky, Dennis,Trinchera, Piera,Yudin, Andrei K.
supporting information, p. 334 - 337 (2013/03/13)
By utilizing amino allenes, aldehydes, and aryl iodides as readily available building blocks, a simple and modular synthesis of multisubstituted pyridines with flexible control over the substitution pattern has been achieved. The method employs a two-step
