41855-73-6

Basic information

• Product Name: N-(4-Methoxyphenyl)-3-pyridylmethyleneamine
• Synonyms: 4-Methoxy-N-(3-pyridinylmethylene)benzenamine;N-(3-Pyridylmethylene)-p-anisylamine;N-(4-Methoxyphenyl)-3-pyridylmethyleneamine;N-(4-Methoxyphenyl)pyridine-3-methanimine
• CAS NO: 41855-73-6
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 0
• Mol File: 41855-73-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Methoxyphenyl)-3-pyridylmethyleneamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxyphenyl)-3-pyridylmethyleneamine(41855-73-6)
• EPA Substance Registry System: N-(4-Methoxyphenyl)-3-pyridylmethyleneamine(41855-73-6)

Safety Data

• Hazardous Substances Data: 41855-73-6(Hazardous Substances Data)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 104-94-9 4-methoxy-aniline 
• 100-17-4 para-methoxynitrobenzene 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 110684-12-3 3-[3-(4-Methoxy-phenyl)-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-pyridine 
• 110684-31-6 3-[3-(4-Methoxy-phenyl)-3H-[1,2,3]triazol-4-yl]-pyridine 
• 59607-99-7 ethyl (E)-3-(pyridin-3-yl)acrylate 
• 1440009-02-8 ((2S,3S)-1-(4-methoxyphenyl)-2-(pyridin-3-yl)piperidin-3-yl)methanol 
• 17708-87-1 5-(pyridin-3-yl)pyrrolidin-2-one 

Relevant articles and documents

Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D)

The occurrence of resistances in Gram negative bacteria is steadily increasing to reach extremely worrying levels and one of the main causes of resistance is the massive spread of very efficient β-lactamases which render most β-lactam antibiotics useless. Herein, we report the development of a series of imino-analogues of β-lactams (namely azetidinimines) as efficient non-covalent inhibitors of β-lactamases. Despite the structural and mechanistic differences between serine-β-lactamases KPC-2 and OXA-48 and metallo-β-lactamase NDM-1, all three enzymes can be inhibited at a submicromolar level by compound 7dfm, which can also repotentiate imipenem against a resistant strain of Escherichia coli expressing NDM-1. We show that 7dfm can efficiently inhibit not only the three main clinically-relevant carbapenemases of Ambler classes A (KPC-2), B (NDM-1) and D (OXA-48) with Ki's below 0.3 μM, but also the cephalosporinase CMY-2 (class C, 86% inhibition at 10 μM). Our results pave the way for the development of a new structurally original family of non-covalent broad-spectrum inhibitors of β-lactamases.

Enantioselective Direct anti-Selective Mannich-type Reactions Catalyzed by 3-Pyrrolidinecarboxylic Acid in the Presence of Potassium Carbonate: Addition of Potassium Carbonate Improves Enantioselectivities

Mannich-type reactions of cyclohexanone and related six-membered-ring ketones with N-p-methoxyphenyl-protected imines of arylaldehydes catalyzed by 3-pyrrolidinecarboxylic acid in the presence of K2CO3 that afford anti-isomers of the Mannich products with

One-pot sequential multicomponent reaction between: In situ generated aldimines and succinaldehyde: Facile synthesis of substituted pyrrole-3-carbaldehydes and applications towards medicinally important fused heterocycles

An efficient sequential multi-component method for the synthesis of N-Arylpyrrole-3-carbaldehydes has been developed. This reaction involved a proline-catalyzed direct Mannich reaction-cyclization sequence between succinaldehyde and in situ generated Ar/H