41860-64-4

Basic information

• Product Name: 4-Fluoro-2-iodo-1-nitrobenzene
• Synonyms: 4-Fluoro-2-iodo-1-nitrobenzene;4-Fluoro-2-iodo-1-nitrobenzene ,95%;Benzene, 4-fluoro-2-iodo-1-nitro-
• CAS NO: 41860-64-4
• Molecular Formula: C₆H₃FINO₂
• Molecular Weight: 266.9963932
• Mol File: 41860-64-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 30 °C
• Boiling Point: 148°C/20mmHg(lit.)
• Appearance: /
• Density: 2.093±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-Fluoro-2-iodo-1-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-iodo-1-nitrobenzene(41860-64-4)
• EPA Substance Registry System: 4-Fluoro-2-iodo-1-nitrobenzene(41860-64-4)

Safety Data

• Hazardous Substances Data: 41860-64-4(Hazardous Substances Data)

Usage

General Description

4-Fluoro-2-iodo-1-nitrobenzene is a compound consisting of a benzene ring with a fluorine, iodine, and nitro group attached to it. It is a derivative of benzene and is commonly used in organic synthesis and pharmaceutical research. As a nitrobenzene derivative, it possesses potential applications in the production of dyes, paints, and agricultural chemicals. Its unique chemical structure makes it a valuable intermediate for the synthesis of various organic compounds and materials. Additionally, it can serve as a useful building block in the development of new pharmaceutical drugs and agrochemicals due to its versatile reactivity and properties.

InChI:InChI=1S/C6H3FINO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H

Upstream product

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• 2369-11-1 5-fluoro-2-nitroaniline 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 

Downstream Products

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• 59541-83-2 5-fluoro-2-phenyl-1H-indole 
• 1225036-85-0 (E)-4-fluoro-1-nitro-2-styrylbenzene 
• 1451270-98-6 C₁₁H₁₄FN 
• 1451270-97-5 4-fluoro-2-(3-methylbut-2-en-1-yl)-1-nitrobenzene 
• 1321627-81-9 4-fluoro-1-nitro-2-(phenylethynyl)benzene 
• 2369-11-1 5-fluoro-2-nitroaniline 
• 1089279-33-3 4-fluoro-1-nitro-2-(2-propen-1-yl)benzene 
• 1089279-29-7 2-ethyl-4-fluoro-1-nitrobenzene 

Relevant articles and documents

Synthetic method of aryl halide taking aryl carboxylic acid as raw material

A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.

Highly stereoselective 7-endo-trig /ring contraction cascade to construct pyrrolo[1,2- a ]quinoline derivatives

With the cooperation of Cram's phenonium ion, a novel cascade reaction was illustrated to construct pyrrolo[1,2-a]quinolines as a sole diastereoisomer in good to excellent yields. Preliminary mechanistic studies revealed that the γ-lactam ring and electron-rich arene are important driving forces for ring contraction.

THE FOUR 6-HALO-7-NITROQUINOXALINES

The study of relative nucleofugicities of nitro and halogen in quinoxalines required the synthesis of the four 6-halo-7-nitroquinoxalines 2a-d.The fluoro-, chloro- and bromo-derivatives were made from the commercially available or readily accessible 1,2-diamino-4-halobenzenes, using the nitration of the corresponding p-toluenesulfonamides.This scheme failed in the case of the iodo compound because of extensive nitro-deiodination.The synthesis of 6-iodo-7-nitroquinoxaline was finally achieved from m-fluoroiodobenzene by taking advantage of the high reactivity of fluorine, compared to iodine, in 2,4-dinitrohalobenzenes.