452-84-6

Usage

Chemical Properties

clear yellow to brown liquid

InChI:InChI=1/C7H8FN/c1-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3

Upstream product

• 442-10-4 1-(2-fluoro-5-methyl-phenyl)-propan-1-one oxime 
• 588-04-5 3,3'-dimethylazobenzene 
• 1403336-96-8 1-(4-chlorophenyl)-2-(m-tolyl)diazene 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 452-62-0 3-bromo-4-fluorotoluene 

Downstream Products

• 1513-25-3 2-chloro-1-fluoro-4-methylbenzene 
• 7420-86-2 5-methyl-2-phenyl-1,3-benzoxazole 
• 106976-08-3 2-(2-Fluoro-5-methyl-phenylamino)-3-nitro-benzoic acid 
• 63762-79-8 2-fluoro-5-methylphenol 
• 21303-50-4 5-methylbenzo[d]thiazole-2(3H)-thione 
• 155310-23-9 2-fluoro-5-methyl-diphenylamine 
• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 
• 128495-45-4 (4-fluoro-3-methoxy-phenyl)methanol 
• 128495-48-7 2-(4-fluoro-3-methoxyphenyl)ethan-1-amine 
• 128495-55-6 N-ethyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-56-7 N-n-propyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 
• 128495-59-0 N,N-di-n-propyl-2-(4-fluoro-3-methoxyphenyl)ethylamine 

Relevant academic research and scientific papers

Synthesis of 2 - fluoro aniline compounds of the method

The invention discloses a method for synthesizing 2 - fluoro aniline compounds of the method, the method is: shown in formula Ia aniline compound of formula Ib α and β shown aniline compound as raw materials, through coupling reaction shown [...] azobenzene compound II, then the type II shown azobenzene compound with a palladium catalyst, fluorination reagent, additive, organic solvent, in the 30 - 150 °C temperature closed agitating the fluorination reaction, [...] compound of formula III, type III compounds are shown in the reaction under the action of a reducing [...] shown IV 2 - fluoro aniline compounds; this invention synthetic 2 - fluoro aniline compounds substrate wide adaptability, mild reaction conditions, the operation is simple, fluorinated and good selectivity, [...] aniline compounds is prepared by many drug molecule is an important intermediate and starting material, wide application prospects.

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

An efficient method for aryl nitro reduction and cleavage of azo compounds using iron powder/calcium chloride

A novel, efficient Fe/CaCl2 system is revealed for the reduction of nitroarenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation (CTH). The selective reduction of nitro compounds in the presence of sensitive functional groups including halides, carbonyl, hydroxyl, aldehyde, methyl, methoxy, acetyl, nitrile, and ester substituents with an excellent yields is reported. The simple experimental procedure and easy purification make the protocol advantageous

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed