452-84-6

Basic information

• Product Name: 2-Fluoro-5-methylaniline
• Synonyms: Benzenamine, 2-fluoro-5-methyl-;2-FLUORO-5-METHYLANILINE;6-FLUORO-M-TOLUIDINE;3-AMINO-4-FLUOROTOLUENE;2-Fluoro-5-methylbenzeneamine ;3-Amino-4-fluorotoluene~6-Fluoro-m-toluidine;2-Fluoro-5-methylbenzenamine;2-Fluoro-5-methylaniline,99%
• CAS NO: 452-84-6
• Molecular Formula: C₇H₈FN
• Molecular Weight: 125.14
• Product Categories: Fluorin-contained toluene series;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Aniline series
• Mol File: 452-84-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 80-86 °C11 mm Hg(lit.)
• Flash Point: 179 °F
• Appearance: Clear yellow to brown/Liquid
• Density: 1.109 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.307mmHg at 25°C
• Refractive Index: n20/D 1.533(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.33±0.10(Predicted)
• BRN: 2715995
• CAS DataBase Reference: 2-Fluoro-5-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-methylaniline(452-84-6)
• EPA Substance Registry System: 2-Fluoro-5-methylaniline(452-84-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-23/24/25
• Safety Statements: 26-36-45-2636/37/39-36/37/39-27
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 452-84-6(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to brown liquid

InChI:InChI=1/C7H8FN/c1-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3

Upstream product

• 588-04-5 3,3'-dimethylazobenzene 
• 1403336-96-8 1-(4-chlorophenyl)-2-(m-tolyl)diazene 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 442-10-4 1-(2-fluoro-5-methyl-phenyl)-propan-1-one oxime 
• 452-62-0 3-bromo-4-fluorotoluene 

Downstream Products

• 63762-79-8 2-fluoro-5-methylphenol 
• 21303-50-4 5-methylbenzo[d]thiazole-2(3H)-thione 
• 3622-48-8 5-methyl-2-methylsulfanyl-1,3-benzothiazole 
• 80945-66-0 (5-methyl-1,3-benzothiazol-2-yl)hydrazine 
• 155310-23-9 2-fluoro-5-methyl-diphenylamine 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 418762-26-2 4-bromo-2-fluoro-5-methylaniline 
• 630119-82-3 2-chloro-N-(2-fluoro-5-methylphenyl)acetamide 
• 476192-37-7 C₁₉H₁₈FN₃O₃ 
• 953802-84-1 ethyl 6-bromo-7-ethoxy-4-[(2-fluoro-5-methylphenyl)amino]quinoline-3-carboxylate 
• 953802-67-0 ethyl 4-[(2-fluoro-5-methylphenyl)amino]-7-(2-methoxyethoxy)-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate 
• 1315692-83-1 1-(2-fluoro-5-methylphenyl)-2,2,5,5-tetramethyl-1,2,5-azadisilolidine 
• 1315692-88-6 3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-fluoro-5-methylaniline 
• 1242606-85-4 C₂₇H₂₇FN₆O 

Relevant articles and documents

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Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed