418776-10-0

Basic information

• Product Name: 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol
• Synonyms: 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol
• CAS NO: 418776-10-0
• Molecular Weight: 381.502
• Mol File: 418776-10-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol(418776-10-0)
• EPA Substance Registry System: 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol(418776-10-0)

Safety Data

• Hazardous Substances Data: 418776-10-0(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 1456620-73-7 N-phenyl-2-{[4-(2-methoxyphenyl)piperazin-1yl]acetyl}hydrazincarbothioamide 
• 204973-87-5 [4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide 
• 63854-11-5 ethyl [4-(2-methoxyphenyl)piperazin-1-yl]acetate 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 

Downstream Products

• 1456620-80-6 1-ethyl-6-fluoro-7-(4-{[(5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetyl}piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Conventional and microwave irradiated synthesis, biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids

Azole derivatives (3, 6) obtained starting from 1-(2-methoxyphenyl)piperazine were converted to the corresponding Mannich bases containing β-lactame or flouroquinolone core via a one pot three component reaction. The synthesis of conazole analogues was carried out starting from triazoles by three steps. Reactions were carried out under conventional and microwave mediated conditions. All the newly synthesized compounds were screened for their antimicrobial, enzyme inhibition and antioxidant activity, and most of them displayed good-moderate activity. Binding affinities and non-covalent interactions between enzyme-ligand complexes were predicted with molecular docking method at molecular level. Docking results complemented well the experimental results on α-glucosidase and urease inhibitory effects of the compounds. Higher binding affinities and much more interaction networks were observed for active compounds in contrary to inactive ones. It was predicted with the docking studies that triazole and anisole moieties in the structure of the synthesized compounds contributed to the stabilization of corresponding enzymes through noncovalent interactions.

Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities

Norfloxacin was converted to 7-(4-amino-2-fluorophenyl)piperazin derivative (2) via the formation of nitro compound. The synthesis of the norfloxacin derivatives containing 1,3-thiazole or 1,3-thiazolidin moiety was performed from the reaction of 4-chloro