41878-54-0Relevant academic research and scientific papers
4-Hydroxy-2-quinolones. 37. Simple synthesis of 1-R-2-oxo-3,4-dihydroxyquinolines
Ukrainets,Taran,Sidorenko,Gorokhova
, p. 1334 - 1336 (2007/10/03)
3-Amino-1-R-2-oxo-4-hydroxyquinolines easily undergo acid hydrolysis with formation of the corresponding 1-R-2-oxo-3,4-dihydroxyquinolines. 1998 Plenum Publishing Corporation.
Antiviral quinolinone compounds
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, (2008/06/13)
Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: STR1 and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1.0. A process for making compounds of Formula 1.0 from the appropriate 3-oximino-quinolin-2,4(1H)-dione (Formula 2.5) is also disclosed. The process comprises reductively hydrolyzing an appropriate 3-oximino-quinolin-2,4(1H)-dione (Formula 2.5) in a mixture with a hydrogenation catalyst and an acidic solvent mixture.
Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful for treating viral infections
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, (2008/06/13)
Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: STR1 and their pharmaceutically acceptable salts and solvates. Pharmaceutical compos
Ylides of Heterocycles, VIII. Reactions of Iodonium-Ylides with Acids
Pongratz, Erik,Kappe, Thomas
, p. 231 - 242 (2007/10/02)
The reaction of various organic and inorganic acids (HX) with iodonium ylides 2 leads to nucleophilic substitution of the iodobenzene substituent by the anion X(-) to yield the heterocycles 5.Some of them are hydrolyzed to the hydroxy compounds 3 or reduced to the starting compounds 1 under the reaction conditions.Reaction of the iodonium ylide 2b with monomethyl sulfate gives the salt 9, which with bases undergoes nucleophilic substitution to compounds 8 and 10-12, respectively, or is converted to 2b again. - Keywords: 3-Acetoxy-4-hydroxy-2-quinolones; 2-Oxoquinoline-4-olates; 3-Substituted 4-hydroxy-2-quinolones
