418784-70-0

Basic information

• Product Name: 1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine
• Synonyms: benzenemethanamine, N-[(4-methoxyphenyl)methyl]-4-nitro-
• CAS NO: 418784-70-0
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.2991
• Mol File: 418784-70-0.mol

Chemical Properties

• Boiling Point: 429.139°C at 760 mmHg
• Flash Point: 213.336°C
• Density: 1.196g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine(418784-70-0)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine(418784-70-0)

Safety Data

• Hazardous Substances Data: 418784-70-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine is used as an active pharmaceutical ingredient for its potential therapeutic effects. 1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine's unique structure allows it to interact with various biological targets, making it a promising candidate for the development of new drugs.
Used in Research and Development:
In the research industry, 1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine is used as a key compound for studying its biological activities and pharmacological properties. This helps scientists understand its potential applications in medicine and drug development.
Used in Organic Synthesis:
1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine also serves as a building block for the synthesis of other organic compounds. Its unique structure makes it a valuable component in the creation of new molecules with specific properties and applications.
Used in Chemical Analysis:
1-(4-methoxyphenyl)-N-(4-nitrobenzyl)methanamine can be employed in chemical analysis to study its interactions with various reagents and conditions. This information can be used to optimize its synthesis and application in different fields.

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 2393-23-9 4-methoxy-benzylamine 
• 555-16-8 4-nitrobenzaldehdye 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Relevant articles and documents

Cs2CO3-Promoted Direct N-Alkylation: Highly Chemoselective Synthesis of N-Alkylated Benzylamines and Anilines

Herein is described an efficient and chemoselective method for the synthesis of diversely substituted secondary amines in yields up to 98 %. Direct mono-N-alkylation of primary benzylamines and anilines with a wide range of alkyl halides is promoted by a cesium base in the absence of any additive or catalyst. The basicity and solubility of cesium carbonate in anhydrous N,N-dimethylformamide not only enables mono-N-alkylation of primary amines but also suppresses undesired dialkylation of the desired amines.

Carbon-carbon bond-forming reactions of α-carbonyl carbocations: Exploration of a reversed-polarity equivalent of enolate chemistry

Carbon-carbon bond-forming reactions of putative α-carbonyl carbocation intermediates generated by Lewis acid- or silver-promoted ionizations of toluenesulfonate or halide leaving groups are described. This under-exploited mode of reactivity represents an 'umpolung' of conventional enolate chemistry, and enables C-C bond construction in both intra- and intermolecular contexts. Attempts to develop diastereoselective variants of this process using chiral ester and oxazolidinone-based auxiliaries are discussed.

1,2,3-Triazole-boranes: Stable and efficient reagents for ketone and aldehyde reductive amination in organic solvents or in water

Air, moisture and thermally stable 1,2,3-triazole-borane complexes were developed as new practical reagents for ketone/aldehyde amination with high efficiency and excellent substrate diversity.

Preparation of benzolactams by Pd(OAC)2-catalyzed direct aromatic carbonylation

We developed a new method for Pd(II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd(OAc)2 and Cu(OAc)2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five- or six-membered benzolactams from secondary ω-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines. Copyright