41879-39-4

Usage

Uses

Used in Chemical Synthesis:
O-(tert-Butyldimethylsilyl)hydroxylamine is used as a reagent in the solid-supported synthesis of hydroxamic acids. It plays a crucial role in inducing the cleavage of these compounds, which are essential in various pharmaceutical and chemical applications.
Used as a Chemical Additive:
O-(tert-Butyldimethylsilyl)hydroxylamine also serves as a chemical additive, enhancing the properties of other substances in various industries. Its unique reactivity allows it to improve the performance of products in which it is incorporated.
Used as an Intermediate:
O-(tert-Butyldimethylsilyl)hydroxylamine is utilized as an intermediate in the synthesis of more complex organic compounds. Its ability to participate in various chemical reactions makes it a valuable component in the development of new materials and products.

Preparation

the reagents are most conveniently prepared by treatment of hydroxylamine hydrochloride with ethylenediamine in dichloromethane, followed by the appropriate chlorosilane.A two-step procedure using ammonia in place of ethylenediamine has also been reported.

InChI:InChI=1/C6H17NOSi/c1-6(2,3)9(4,5)8-7/h7H2,1-5H3

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 126754-42-5 (E)-trans-2-methoxy-3-methylcyclohexanone O-(tert-butyldimethylsilyl)oxime 
• 88589-69-9 (E)-cis-4-tert-Butyl-2-chlorocyclohexan-1-one (tert-butyldimethylsilyl)oxime 
• 93184-33-9 C₁₈H₃₄ClNO₂Si 
• 93184-32-8 C₁₉H₃₆ClNO₂Si 
• 3391-10-4 (S)-1-(4-Chlorophenyl)ethanol 
• 3391-10-4 (R)-1-(4-chlorophenyl)ethan-1-ol 
• 208924-67-8 O-tert-butyldimethylsilyl-p-methoxybenzohydroxamic acid 
• 285572-40-9 (phenylsulfanyl)heptanoic acid (tert-butyldimethylsilyl)hydroxyamide 
• 1026034-55-8 C₂₀H₃₅NO₃SSi 
• 400090-91-7 C₁₉H₂₅N₃O₆SSi 

Relevant academic research and scientific papers

PENICILLIN-BINDING PROTEIN INHIBITORS

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

A Concise Enantioselective Total Synthesis of (?)-Virosaine A

The total synthesis of (?)-virosaine A (1) was achieved in ten steps starting from furan and 2-bromoacrolein. A one-pot Diels–Alder cycloaddition/organolithium addition initiated an efficient sequence to access a key oxime/epoxide intermediate. Heating this intermediate in acetic acid resulted in an intramolecular epoxide opening/nitrone [3+2] cycloaddition cascade to construct the caged core of 1 in a single step. Several methods of C?H functionalization were assessed on the cascade product, and ultimately, a directed lithiation/bromination effected selective C14 functionalization, enabling the synthesis of 1.

O-TBS-N-tosylhydroxylamine: A reagent for facile conversion of alcohols to oximes

(Chemical Equation Presented) A variety of oximes were synthesized from the corresponding alcohols, alkyl halides, or alkyl sulfonates without using external oxidants. With this simple two-step procedure involving substitution with readily available TsNHOTBS and subsequent treatment with CsF, a range of oximes were prepared including the ones hardly preparable with conventional procedures.

Synthetic methodology for the preparation of N-hydroxysulfamides

A convenient synthesis of a variety of substituted N-hydroxysulfamides from chlorosulfonyl isocyanate is reported. Alkyl groups can be introduced selectively on the N-Boc nitrogen of key intermediates 1a or 1b using the Mitsunobu reaction with alcohols. S

New C-3′ hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents

Syntheses of a series of new C-3′ hydroxamate-substituted cephalosporin derivatives with potent antibacterial and media-dependent anti-TB activity are described. The Royal Society of Chemistry 2006.