41881-82-7

Upstream product

• 95-16-9 1,3-Benzothiazole 
• 105-37-3 Ethyl propionate 
• 1809-21-8 di-n-propyl phosphonate 
• 181048-91-9 1-(benzo[d]thiazol-2-yl)prop-2-en-1-ol 
• 2987-53-3 2-(Methylthio)aniline 
• 18550-49-7 N-formyl-o-thioanisidine 
• 79-03-8 propionyl chloride 
• 175694-99-2 (2-isocyanophenyl)(methyl)sulfane 
• 39582-59-7 benzothiazol-2-yl-lithium 
• 123-38-6 propionaldehyde 

Relevant academic research and scientific papers

NCS/TBHP promoted C2 arylation of benzothiazoles with aldehydes in DMSO

A N-chlorosuccinimide catalyzed oxidative synthesis of 2-aryl benzothiazole from benzothiazoles and aryl aldehydes using tert-butyl peroxybenzoate as an oxidant in dimethyl sulfoxide (DMSO) has been developed in moderate to good yields. Solvent DMSO as a strong Lewis base plays an efficient role in the reaction. Various substrates were tolerated under optimized conditions affording the arylated products in 12–94% yields for 28 examples. Additionally, acylated benzothiazoles were produced with 4 examples.

Peroxides as "switches" of dialkyl H-phosphonate: Two mild and metal-free methods for preparation of 2-acylbenzothiazoles and dialkyl benzothiazol-2-ylphosphonates

Two mild and metal-free methods for the preparation of two kinds of important benzothiazole derivatives, 2-acylbenzothiazoles and dialkyl benzothiazol-2-ylphosphonates, respectively, were developed. The dialkyl H-phosphonate (RO)2P(O)H exists i

Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride

We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.

Benzazole compounds and their use

The present invention discloses a method for repelling insects, mites and ticks from warm-blooded animals with a benzazole compound.

Studies on isocyanides. 2-Isocyanothioanisole, a synthetic equivalent of the benzothiazol-2-YL anion

A synthesis of 2-isocyanothioanisole (3) is described. The reaction between 3 and electrophilic reagents took place easily to give 2-functionalized benzothiazoles (6).

General Reactivity of 2-Lithiobenzothiazole to Various Electrophiles and the Use as a Formyl Anion Equivalent in the Synthesis of α-Hydroxy Carbonyl Compounds

The reaction of 2-lithiobenzothiazole with a variety of electrophiles such as aldehydes, ketones, carboxylic esters, lactones, nitriles, and amides afforded the expected addition and substitution products.Trimethylsilyl chloride readily reacted with the b

KETONE-GENERATING REACTION OF 3-METHYL-2-(1'-HYDROXYDIALKYLMETHYL)BENZOTHIAZOLIUM IODIDE UNDER BASIC CONDITIONS

Quaternized benzothiazol-2-yl moiety was found to be a good leaving group in the ketone-generating reaction of 3-methyl-2-(1'-hydroxydialkylmethyl)benzothiazolium iodides.The benzothiazolium salts easily obtained from ketones via methylation of 2-(1'-hydroxydialkylmethyl)benzothiazoles with methyl iodide, produced the corresponding ketones in excellent yields by the treatment with a variety of bases.Aldehydes and carboxylic esters were convertible to ketones by using the present methodology.