41888-28-2

Upstream product

• 99-88-7 4-Isopropylaniline 
• 98-82-8 Isopropylbenzene 

Downstream Products

• 80991-24-8 1,5-Bis-(4-isopropyl-phenyl)-3-nitro-formazan 
• 82588-06-5 9-[(4-Isopropyl-phenyl)-hydrazono]-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid 
• 144122-26-9 1-(4'-isopropylphenyl)-3,5-diphenyl-formazan 
• 83454-28-8 1,5-bis-(4-isopropyl-phenyl)-thiocarbazone 
• 93599-24-7 [1-[5-(4-Isopropyl-phenyl)-thiophen-2-yl]-eth-(E)-ylideneaminooxy]-acetic acid ethyl ester 
• 93599-23-6 1-[5-(4-Isopropyl-phenyl)-thiophen-2-yl]-ethanone O-(2-diethylamino-ethyl)-oxime 
• 93599-33-8 1-[5-(4-Isopropyl-phenyl)-thiophen-2-yl]-ethanone oxime 
• 144122-27-0 1-(4'-isopropylphenyl)-3,5-diphenyl-verdazyl 

Relevant academic research and scientific papers

Telescoped Sequence of Exothermic and Endothermic Reactions in Multistep Flow Synthesis

A multistep sequential flow synthesis of isopropyl phenol is demonstrated, involving 4-step exothermic, endothermic, and temperature sensitive reactions such as nitration, reduction, diazotization, and high temperature hydrolysis. Nitration of cumene with fuming nitric acid produces 2- A nd 4-nitrocumene which are converted into respective cumidines by the hydrogenation using Pd/Ni catalyst in H-cube with gravity separation. Hydrolysis of in situ generated diazonium salts in the boiling acidic conditions is carried out using integration of flow and microwave-assisted synthesis. 58% of 4-isopropyl phenol was obtained. The sequential flow synthesis can be applied to synthesize other organic compounds involving this specific sequence of reactions.

Synthesis and Pharmacology of Some New Oxime Ethers Derived from 2-Acetyl-5-arylthiophenes

Several new 5-arylthiophene-2-acetoxime ethers (1-28) have been synthesised and screened for their pharmacological activities.Some of these compounds possess moderate antiinflammatory and mild CNS depressant activities.The intermediate 2-acetyl-5-(p-ethyl/p-iso-propyl/3,4-dimethylphenyl)thiophenes (1b-d) and their oximes (IIb-d) have been reported for the first time.