41888-85-1

Upstream product

• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 543-27-1 isobutyl chloroformate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 15028-44-1 DL-phenylalanine methyl ester 
• 84814-44-8 2,3,4,6-tetra-O-acetyl-1-O-(N-benzyloxycarbonylglycyl)-α-D-glucopyranose 
• 84814-40-4 2,3,4,6-tetra-O-acetyl-1-O-(N-benzyloxycarbonylglycyl)-β-D-glucopyranose 
• 28836-50-2 2,3,4,6-tetra-O-benzyl-1-O-(N-benzyloxycarbonylglycyl)-β-D-glucopyranose 
• 2899-58-3 1,3-dioxoisoindolin-2-yl ((benzyloxy)carbonyl)glycinate 
• 2899-56-1 N-benzyloxycarbonylglycine cyanomethylester 
• 15050-24-5 N-(benzyloxycarbonyl)glycyl chloride 

Downstream Products

• 3338-37-2 N-(N-benzyloxycarbonyl-glycyl)-phenylalanine cyanomethyl ester 
• 30189-49-2 N-(N-benzyloxycarbonyl-glycyl)-phenylalanine benzylamide 
• 5540-03-4 Z-Gly-DL-Phe 
• 36123-82-7 N-(N-benzyloxycarbonyl-glycyl)-phenylalanine amide 

Relevant academic research and scientific papers

THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE

[PROBLEMS] To provide a neuronal cell death inhibitor and a therapeutic agent for a neurodegenerative disease, particularly Perkinson's disease. [MEANS FOR SOLVING PROBLEMS] It is known that DJ-1 protein is involved in Perkinson's disease and is capable o

PEPTIDE BOND FORMATION BY INTERMOLECULAR AMINOLYSIS OF D-GLUCOPYRANOSYL ESTERS OF AMINO ACIDS

The reaction of HO-protected and -unprotected D-glucopyranosyl esters of N-acylamino acids (Gly, Ala, Phe) with glycine and phenylalanine methyl esters in N,N-dimethylformamide at 38 deg C and dichloromethane at 40 deg C, respectively, led to repture of the C-1 ester bond and formation of the corresponding N-acyldipeptide methyl ester.The relative reactivity of the C-1 ester bond toward aminolysis was greatly influenced by the structure of the amino acid nucleophile, the nature of the aglycon side-chain group, and the anomeric configuration of the D-glucopyranosyl ester involved.Evidence for a substantially lower acylating efficiency of the ester at C-2, as compared to that at C-1, was obtained by aminolysis of two fully acetylated 2-O-(acylaminoacyl)-β-D-glucopyranoses.Treatment of 1-O-(glycylglycylglycyl)-β-D-glucopyranose with phenylalanine methyl ester in N,N-dimethylformamide led to parallel hydrolysis and intermolecular aminolysis, to give the tripeptide and tetrapeptide methyl ester.