41891-88-7Relevant academic research and scientific papers
A convenient method for the preparation of oligonucleotide 5′-phosphates
Garcia-Echeverri, Carlos,Haener, Robert
, p. 3933 - 3938 (1996)
Oligodeoxyribonucleotides (4-, 5-, and 11-mer) bearing a 5′-phosphate group have been synthesized using 2-n-decylthioethyl as protecting group of the 5′-terminaI phosphate function. The lipophilic protecting group, which is easily available from 1-bromo-n-decane and 2-mercaptoethanol, allows a simple and efficient purification of the oligonucleotides. It is quantitatively removed by oxidation of the sulfide to the sulfoxide, followed by β-elimination in aqueous base media.
Sulfur makes the difference: Synthesis and mesomorphic properties of novel thioether-functionalized imidazolium ionic liquid crystals
Mansueto, Markus,Kre?, Katharina Christina,Laschat, Sabine
, p. 6258 - 6264 (2015/03/30)
Novel thioether-linked imidazolium ionic liquid crystals were synthesized starting from methyl 2-mercaptoacetate. The mesomorphic properties were determined by differential scanning calorimetry (DSC), polarizing optical microscopy (POM), and X-ray diffraction. All mesogens displayed smectic A mesophase geometries with strongly interdigitated bilayer structures. Comparison of the thioether-linked imidazolium salts with the corresponding amine- and amide-linked imidazolium salts as well as simple N-alkyl-imidazolium salts showed that both mesophase width and stability increased with increasing softness of the linking unit, thus indicating the beneficial effect of sulfur. Additionally, an increase of the length of the linking unit decreased the interdigitation of the alkyl chains.
On the Use of Hydrophobic Probes in the Chromatographic Purification of Solid-phase-synthesized Peptides
Garcia-Echeverria, Carlos
, p. 779 - 780 (2007/10/02)
A strategy for the reversed-phase chromatographic purification of solid-phase-synthesized peptides is described and illustrated by the synthesis of a 23-mer model peptide; the target peptide is distinguished from terminated by-products by the attachment of a hydrophobic probe to the resin-bound peptide.
REACTIONS OF OXIRANES WITH ALKYLTHIOLS
Chlebicki, Jan,Cichacz, Zbigniew
, p. 485 - 494 (2007/10/02)
Alkyl-2-hydroxyalkyl sulfides and their oxyalkylenated adducts were obtained in the reaction of oxirane or methyloxirane with C4-C12 alkylthiols in presence of basic or acidic catalysts.The sulfides were further oxidized to sulfoxides and sulfones.
