41927-29-1Relevant academic research and scientific papers
Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade Reactions: Facile Synthesis of Profens
Fu, Kaiyue,Ma, Yu,Sun, Yaxin,Tang, Bo,Yang, Guang,Yang, Peng,Yue, Jieyu,Zhang, Li,Zhou, Jianrong Steve
supporting information, (2021/11/22)
We report a stereoselective conversion of terminal alkynes to α-chiral carboxylic acids using a nickel-catalyzed domino hydrocarboxylation-transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti-inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.
Enzyme-Inspired Chiral Secondary-Phosphine-Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation
Chen, Caiyou,Zhang, Zhefan,Jin, Shicheng,Fan, Xiangru,Geng, Mingyu,Zhou, Yan,Wen, Songwei,Wang, Xinrui,Chung, Lung Wa,Dong, Xiu-Qin,Zhang, Xumu
supporting information, p. 6808 - 6812 (2017/06/06)
Inspired by the unique character of enzymes, we developed novel chiral SPO (secondary-phosphine-oxide) ligand (SPO-Wudaphos) which can enter into both ion pair and H-bond noncovalent interactions. The novel chiral SPO-Wudaphos exhibited excellent results
SPIRO PHOSPHORUS-OXAZOLINE, SYNTHESIS AND USE THEREOF
-
Page/Page column 13, (2011/02/17)
The present invention belongs to a spiro phosphine-oxazoline and preparation method and application thereof, particularly, publishes a novel spiro phosphine-oxazoline and the preparation method of its iridium complex. The substituted 7-diaryl phosphino-7'-carboxy-1,1'-Lo-dihydro-indene is used as the starting raw material to synthesize the novel spiro phosphine-oxazoline of the present invention through a two-step reaction. The novel spiro phosphine-oxazoline and the iridium precursor are complexed to become a complex, and then through ion exchange, an iridium/phosphine spiro-oxazoline complex with different anions can be obtained. The present invention overcomes the shortcomings of the existing technology. The cheap readily available amino alcohol is used as the raw material to synthesize the novel spiro phosphine-oxazoline, on the fourth position of the oxazoline ring of which there is no substituent. The iridium complex of this novel spiro phosphine-oxazoline can catalyze the asymmetric hydrogenation of α-substituted acrylic acid, and shows very high activity and enantioselectivity, therefore has a vey high research value and an industrialization prospect.
Highly diastereoselective preparation of (E)-alkenylsilanes bearing an α-chiral center
Perrone, Sylvie,Knochel, Paul
, p. 1041 - 1044 (2008/02/01)
(Chemical Equation Presented) The copper(I)-mediated anti-S N2′ allylic substitution allows a highly stereoselective preparation of alkenylsilanes bearing a chiral center in the α-position with high transfer of chirality. These alkenylsilanes were converted into α,β-unsaturated ketones or into the corresponding boronic esters without loss of the chiral information.
The asymmetric hydrogenation of 2-phenethylacrylic acid as the key step for the enantioselective synthesis of Citralis Nitrile
Scrivanti, Alberto,Bovo, Sara,Ciappa, Alessandra,Matteoli, Ugo
, p. 9261 - 9265 (2008/02/10)
A catalytic approach to the enantioselective synthesis of Citralis Nitrile (3-methyl-5-phenyl-pentanenitrile, a citrus-type odorant) is described. The key step is the transition-metal catalyzed asymmetric hydrogenation of 2-phenethylacrylic aci
Efficient and selective synthesis of 6,7-dehydrostipiamide via Zr-catalyzed asymmetric carboalumination and Pd-catalyzed cross-coupling of organozincs
Zeng, Xingzhong,Zeng, Fanxing,Negishi, Ei-Ichi
, p. 3245 - 3248 (2007/10/03)
(Chemical Equation Presented) 6,7-Dehydrostipiamide has been synthesized in 23% yield in 15 steps in the longest linear sequence through the application of the Zr-catalyzed asymmetric carboalumination and the Pd-catalyzed organozinc cross-coupling in addi
EFFECT OF THE MUTUAL POSITION OF THE CHROMOPHORES ON THE CHIRAL-OPTICAL CHARACTERISTICS OF THE ALIPHATIC-AROMATIC ACIDS WITH AN ASYMMETRIC ATOM AT THE α POSITION TO THE CARBONYL GROUP
Potatov, V. M.,Dem'yanovich, V. M.,Vendrova, O. E.,Strel'tsova, E. S.
, p. 2080 - 2083 (2007/10/02)
The circular dichroism of (-)-2-methyl-4-phenylbutyric acid was investigated, and a comparison was made with (-)-2-phenylpropionic and (-)-2-methyl-3-phenylpropionic acids.It was shown that the position and magnitude of the Cotton effect in the region of
