41930-23-8Relevant academic research and scientific papers
Regioselective iodoazidation of alkynes: Synthesis of α,α-diazidoketones
Okamoto, Noriko,Sueda, Takuya,Minami, Hideki,Miwa, Yoshihisa,Yanada, Reiko
, p. 1336 - 1339 (2015)
Aryl alkyl alkynes reacted with N-iodosuccinimide (NIS) and trimethylsilyl azide (TMSN3), leading to α,α-diazidoketones via the regioselective addition of IN3 to alkynes. Huisgen cyclization of α,α-diazidoketones generated bis-triazo
Metal-Free Regioselective Chloroazidation of Internal Alkynes
Huang, Bin,Liffert, Raphael,Linden, Anthony,Gademann, Karl
, p. 981 - 984 (2019/01/04)
A metal-free, room temperature protocol for the regioselective chloroazidation of internal alkynes is disclosed. The reactions of internal alkynes with trimethylsilyl azide (TMSN3) in the presence of 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) afforded the corresponding chloroazidoalkenes in good yields. This reaction has good functional group tolerance and is operationally simple.
