41954-28-3

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 91-59-8 naphthalen-2-ylamine 

Downstream Products

• 247138-30-3 5-(4-chloro-phenyl)-2,3,5,6-tetrahydro-1H-benzo[a]phenanthridin-4-one 
• 27007-25-6 8-(4-Chloro-phenyl)-7-aza-indeno[2,1-c]phenanthren-9-one 
• 64257-45-0 1-(4-chlorophenyl)-1,2-dihydrobenzo[f]quinolin-3(4H)-one 
• 97152-64-2 3-(4-chlorophenyl)-2-phenylbenzo[f]quinoline 
• 1049682-40-7 3-(4-chlorophenyl)-2-methylbenzo[f]quinoline 
• 1049682-50-9 3-(4-chlorophenyl)-2-ethylbenzo[f]quinoline 
• 1574312-65-4 3-(4-chlorophenyl)-1-phenyl-1,2,3,4-tetrahydrobenzo[f]quinazoline 
• 1574312-66-5 3-(4-chlorophenyl)-1-(4-methylphenyl)-1,2,3,4-tetrahydrobenzo[f]quinazoline 
• 97306-78-0 N-(4-chlorobenzyl)-2-aminonaphthalene 
• 107805-78-7 1-Acenaphthen-5-yl-3-(4-chloro-phenyl)-benzo[f]quinoline 
• 22319-78-4 3-(4-chloro-phenyl)-1-thiophen-2-yl-benzo[f]quinoline 
• 28707-37-1 3-(4-chlorophenyl)benzo[f]quinoline 

Relevant academic research and scientific papers

Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation

Androgen receptor (AR) plays important roles in the development of prostate cancer (PCa), and therefore it has been regarded as the most important therapeutic target for both hormone-sensitive prostate cancer (HSPC) and advanced PCa. In this study, a nove

Rhodium-Catalyzed Dehydrogenative Annulation of N-Arylmethanimines with Vinylene Carbonate for Synthesizing Quinolines

Here we report a novel Rh-catalyzed C-H/C-H alkenylation of N-arylmethanimines with vinylene carbonate acting as a vinylene unit. Forty examples of C3,C4-nonsubstituted quinolines were achieved from commercially available starting materials. This identified process features an exceedingly simple system, a lower loading of catalyst, and the capacity for postfunctionalization with bioactive molecules.

Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells

To produce a novel class of anticancer compounds, an efficient method for synthesizing novel β-lactone and β-lactam frameworks was developed based on the reaction of a new ketene with C=O and C=N bonds. Functionalized 2-azetidinones were efficiently synthesized by employing 2,4-dichlorophenoxylketene, which was generated in situ. The reaction of the ketene with aldehydes was not successful and in all cases except for 4-nitrobenzaldehyde, a rearranged dimer of the ketene was obtained as a lactone. Anticancer cellular activity of all new β-lactams and lactones on breast cancer cells was studied. All new synthesized compounds exhibited potential anticancer activity which may guarantee their future application in moderate chemotherapy.

One-pot three-component synthesis of benzo[f]thiopyrano[3,4-b]quinolin- 11(8H)-one derivatives

A series of novel benzo[f]thiopyrano[3,4-b]quinolin-11(8H)-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5(4H,6H)- dione, and β-naphthylamine in glacial acetic acid. This protocol features mild reaction conditions, hig

An efficient method for the synthesis of indolo[3,2-c]quinoline derivatives catalyzed by iodine

The reaction of Schiff base and indole catalyzed by iodine in DMA, subsequently treated with DDQ, gave indolo[3,2-c]quinoline derivatives in good yields. The structure of 3e was confirmed by X-ray diffraction analysis. The reaction of Schiff base and indo

A stereoselective Povarov reaction leading to exo-tetrahydroindolo[3,2-c] quinoline derivatives catalyzed by iodine

We report an iodine-catalyzed Povarov reaction using indole as dienophile carried out in toluene at room temperature. This three-component reaction, coupling an aldehyde, an amine, and an indole, proved to be an efficient method for synthesizing exo-indol

Synthesis of ethyl 2-hydroxy-3-[aryl(2-naphthylamino)methyl]-2-cyclopentenecarboxylates and ethyl 3-arylmethylene-2-(2-naphthylamino)-1-cyclopentenecarboxylates

Condensation of N-arylmethylene-2-naphthylamines with ethyl 2-oxocycopentanecarboxylate in the presence of HCl or CH3COOH yields ethyl 2-hydroxy-3-[aryl(2-naphthylamino)methyl]-2-cyclopentene-carboxylates and ethyl 3-arylmethylene-2-(2-naphthyl

Synthesis of 5-aryl-1,2,3,4-tetrahydrobenzo[a]phenanthridines

Previously unknown derivatives of tetrahydro[a]phenanthridine containing annelated benzoquinoline and cyclohexene nuclei were prepared by condensation of azomethines of the 2-naphthylamine series with cyclohexanone. The possibility of synthesis of such compounds without preliminarily preparing Schiff bases was demonstrated. The effect of substituents in the aromatic ring of the azomethine on the yield of the target products was elucidated. The IR, UV, 1H NMR, and mass spectra of the synthesized compounds were discussed.