41964-02-7

Basic information

• Product Name: 5-(4-chloro-phenoxy)-1H-pyrimidin-2-one
• Synonyms: 5-(4-chloro-phenoxy)-1H-pyrimidin-2-one
• CAS NO: 41964-02-7
• Molecular Weight: 222.631
• Mol File: 41964-02-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-chloro-phenoxy)-1H-pyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chloro-phenoxy)-1H-pyrimidin-2-one(41964-02-7)
• EPA Substance Registry System: 5-(4-chloro-phenoxy)-1H-pyrimidin-2-one(41964-02-7)

Safety Data

• Hazardous Substances Data: 41964-02-7(Hazardous Substances Data)

Upstream product

• 57-13-6 urea 
• 106-48-9 4-chloro-phenol 
• 41964-04-9 1-chloro-4-(2,2-diethoxyethoxy)benzene 

Relevant articles and documents

Bronchodilator and Antiulcer Phenoxypyrimidinones

Series of 5-phenoxy-2(1H)-pyrimidinones, 5-phenoxy-4(3H)-pyrimidinones, and related compounds were prepared in a follow-up of a lead prepared as a potential cyclic nucleotide regulating agent.Compounds were evaluated for bronchodilator activity in histamine-challenged guinea pigs and for antiulcer activity in a cold-restraint, stressed rat ulcer model.Bronchodilator activity comparable to, or greater than, that of theophylline was found in both the 2(1H)- and 4(3H)-pyrimidinone series and was most prominent in analogues containing either an electron-withdrawing or -donating substituent in the para position of the phenoxy ring.Significant antiulcer activity was observed only in the 2(1H)-pyrimidinone series among three closely related analogues.One of these, 5-(m-methylphenoxy)-2(1H)-pyrimidinone (3), exhibited more potent antiulcer effects than the clinically useful antiulcer agent carbenoxolone, without demonstrating bronchodilator activity.