41964-04-9

Basic information

• Product Name: 1-Chloro-4-(2,2-diethoxyethoxy)benzene
• Synonyms: 1-(4-Chlorophenoxy)-2,2-diethoxyethane;1-Chloro-4-(2,2-diethoxyethoxy)benzene
• CAS NO: 41964-04-9
• Molecular Formula: C₁₂H₁₇ClO₃
• Molecular Weight: 244.71
• Mol File: 41964-04-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 145 °C(Press: 8 Torr)
• Appearance: /
• Density: 1.116 g/cm3(Temp: 25 °C)
• CAS DataBase Reference: 1-Chloro-4-(2,2-diethoxyethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-(2,2-diethoxyethoxy)benzene(41964-04-9)
• EPA Substance Registry System: 1-Chloro-4-(2,2-diethoxyethoxy)benzene(41964-04-9)

Safety Data

• Hazardous Substances Data: 41964-04-9(Hazardous Substances Data)

Upstream product

• 106-48-9 4-chloro-phenol 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 107-20-0 2-chloroethanal 

Downstream Products

• 18761-36-9 5-chloro-2-phenylbenzofuran 
• 61756-72-7 (4-chloro-phenoxy)-acetaldehyde-semicarbazone 
• 29595-88-8 4-(4-chloro-phenoxy)-trans-crotonic acid 
• 67993-02-6 2C₉H₁₁ClN₄O*H₂O₄S 
• 43018-72-0 p-chlorophenoxyacetaldehyde 
• 43018-78-6 1,3-Bis-(4-chloro-phenoxy)-7-dimethylamino-heptane-2,4-diol 
• 43018-74-2 1-p-Chlorphenoxy-5-dimethylamino-pentanol-⁽²⁾ 
• 41964-02-7 5-(4-chloro-phenoxy)-1H-pyrimidin-2-one 

Relevant articles and documents

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochemical model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug molecule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asymmetric C–C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

Direct Dimesitylborylation of Benzofuran Derivatives by an Iridium-Catalyzed C?H Activation with Silyldimesitylborane

Direct dimesitylborylation of benzofuran derivatives by a C?H activation catalyzed by an iridium(I)/N-heterocyclic carbene (NHC) complex in the presence of Ph2MeSi-BMes2 afforded the corresponding dimesitylborylation products in good to high yield with excellent regioselectivity. This method provides a straightforward route to donor–(π-spacer)–acceptor systems with intriguing solvatochromic luminescence properties.

Visible light-induced monofluoromethylenation of heteroarenes with ethyl bromofluoroacetate

Visible light-induced monofluoromethylenation of benzofurans and benzothiophenes with ethyl bromofluoroacetate was developed. This method provided a convenient access to novel α-fluoro-α-heteroarylesters under mild reaction conditions.