41964-42-5Relevant articles and documents
Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands
Braganza, Chriselle D.,Motozono, Chihiro,Shibata, Kensuke,Sonoda, Koh-Hei,Stocker, Bridget L.,Timmer, Mattie S. M.,Yamasaki, Sho
, p. 5291 - 5294 (2020)
Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified. This journal is