41967-03-7Relevant academic research and scientific papers
Liquid phase organic synthesis of 3,5-disubstituted 1,3,5-thia-diazinane-2- thione derivatives on polyethylene glycol (PEG) support
Rodriguez, Hortensia,Coro, Julieta,Suarez, Margarita,Martinez-Alvarez, Roberto,Martin, Nazario,Albericio, Fernando
, p. 326 - 338 (2013/01/15)
An efficient liquid-phase synthesis of 3,5-disubstituted 1,3,5-thiadiazinane-2-thione derivatives (THTT) is described using soluble polymer support polyethylene glycol (PEG) 5000 via one-pot condensation of PEG-bound free amino acid or PEG-bound tripeptid
Synthesis and antiprotozoan properties of new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives
Ochoa, Carmen,Perez, Eduardo,Perez, Roland,Suarez, Margarita,Ochoa, Estael,Rodriguez, Hortensia,Gomez Barrio, Alicia,Muclas, Susana,Jose Nogal, Juan,Martinez, Rafael A.
, p. 764 - 769 (2007/10/03)
In a search for antiprotozoan compounds, 34 new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them showed important antiprotozoan a
New prodrug approach for amino acids and amino-acid-like drugs
Aboul-Fadl,El-Shorbagi
, p. 165 - 169 (2007/10/03)
A series of disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives 4a-g were prepared and found to be promising prodrugs for amino acids and similar compounds. The pH profile for the degradation of the THTT derivatives in aqueous buffer solutions was determined using HPLC and was accounted for in terms of specific base-catalyzed reactions. The compounds, however, showed high acid stability. Enzymatic hydrolysis (human serum) of the derivatives offered an advantageous range of t( 1/2 ) values, which may be useful in controlling the onset and the duration of action of drugs.
