41967-43-5Relevant academic research and scientific papers
Microwave-mediated solvent free Rap-Stoermer reaction for efficient synthesis of benzofurans
Rao, Maddali L.N.,Awasthi, Dheeraj K.,Banerjee, Debasis
, p. 431 - 434 (2007)
The Rap-Stoermer reaction of salicylaldehydes with diverse phenacyl bromide and phenacyl iodides proceeded cleanly to afford various functionalized benzofurans in excellent yields under base-mediated solvent free microwave irradiation conditions.
Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies
Ali, Basharat,Ali, Irfan,Chigurupati, Sridevi,Iqbal, Muhammad Shahid,Ji, Xingyue,Khan, Khalid Mohammed,Perveen, Shahnaz,Rafique, Rafaila,Rehman, Ashfaq Ur,Salar, Uzma,Taha, Muhammad,Wadood, Abdul
, (2020/09/11)
Thirty benzofuran-2-yl(phenyl)methanones 1–30 were synthesized and characterized their structures by spectroscopic techniques. Substituted phenacyl bromide and different derivatives of 2-hydroxy-benzaldehyde treated in the presence of anhydrous K2/s
Tandem addition/cyclization for synthesis of 2-aroyl benzofurans and 2-aroyl indoles by carbopalladation of nitriles
Gong, Julin,Hu, Kun,Shao, Yinlin,Li, Renhao,Zhang, Yetong,Hu, Maolin,Chen, Jiuxi
, p. 488 - 494 (2020/02/03)
The first example of the palladium-catalyzed tandem addition/cyclization of 2-(2-acylphenoxy)acetonitriles with arylboronic acids has been developed, providing a new strategy for the synthesis of 2-aroyl benzofurans with excellent chemoselectivity and wid
A general approach to intermolecular carbonylation of arene C-H bonds to ketones through catalytic aroyl triflate formation
Kinney, R. Garrison,Tjutrins, Jevgenijs,Torres, Gerardo M.,Liu, Nina Jiabao,Kulkarni, Omkar,Arndtsen, Bruce A.
, p. 193 - 199 (2018/02/06)
The development of metal-catalysed methods to functionalize inert C-H bonds has become a dominant research theme in the past decade as an approach to efficient synthesis. However, the incorporation of carbon monoxide into such reactions to form valuable ketones has to date proved a challenge, despite its potential as a straightforward and green alternative to Friedel-Crafts reactions. Here we describe a new approach to palladium-catalysed C-H bond functionalization in which carbon monoxide is used to drive the generation of high-energy electrophiles. This offers a method to couple the useful features of metal-catalysed C-H functionalization (stable and available reagents) and electrophilic acylations (broad scope and selectivity), and synthesize ketones simply from aryl iodides, CO and arenes. Notably, the reaction proceeds in an intermolecular fashion, without directing groups and at very low palladium-catalyst loadings. Mechanistic studies show that the reaction proceeds through the catalytic build-up of potent aroyl triflate electrophiles.
2,3-Diaroyl benzofurans from arynes: Sequential synthesis of 2-aroyl benzofurans followed by benzoylation
Neog, Kashmiri,Das, Babulal,Gogoi, Pranjal
, p. 3138 - 3150 (2018/05/17)
A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C-O and C-C bond cleavage as well as C-O and C-C bond formation in a single reaction vessel. The methodology provides good yields of 2-aroyl benzofurans and tolerates a variety of functional groups. The synthesized 2-aroyl benzofurans were further benzoylated at 3-positions and one of the synthesized 2,3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.
Syntheses of 2-Aroyl Benzofurans through Cascade Annulation on Arynes
Gouthami, Pashikanti,Chavan, Lahu N.,Chegondi, Rambabu,Chandrasekhar, Srivari
, p. 3325 - 3332 (2018/03/25)
The highly efficient and expedient route for the syntheses of 2-aroyl benzofurans has been developed via the cascade [2+2] followed by a [4+1] annulation on arynes. The overall transformation proceeded through the formation of ortho-quinone methide by the
Copper(I)-Catalyzed Chemoselective Reduction of Benzofuran-2-yl Ketones to Alcohols with B2pin2 via a Domino-Borylation-Protodeboronation Strategy
Xuan, Qingqing,Kong, Weiguang,Song, Qiuling
, p. 7602 - 7607 (2017/07/26)
A novel copper(I)-catalyzed chemoselective reduction of the carbonyls of benzofuran-2-yl ketones over furan rings with B2pin2 has been developed. This reaction proceeded under mild conditions. High valuable secondary alcohol derivatives of benzofurans were obtained in good to excellent yields with a broad substrate scope. The mechanistic studies suggested that a domino-borylation-protodeboronation pathway was involved in this reaction.
Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives
Xu, Wengang,Li, Qingcui,Cao, Chuanpeng,Zhang, Fanglin,Zheng, Hua
, p. 6158 - 6161 (2015/06/08)
A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.
DABCO-promoted efficient and convenient synthesis of benzofurans
Meshram,Reddy, B. Chennakesava,Prasad,Goud, P. Ramesh,Kumar, G. Santosh,Kumar, R. Naveen
experimental part, p. 1669 - 1676 (2012/05/04)
An efficient and convenient synthesis of benzofurans has been described from phenacyl halides and o-hydroxy benzaldehyde in the presence of DABCO. The procedure is applicable for a variety of phenacyl halides and provide a variety of benzofurans. DABCO ac
