40805-62-7

Upstream product

• 4209-24-9 p-methylphenacyl chloride 
• 122-00-9 para-methylacetophenone 
• 33675-56-8 1-(iodoethynyl)-4-methylbenzene 
• 622-96-8 4-methylethylbenzene 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 67-56-1 methanol 
• 766-97-2 4-n-methylphenylacetylene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 335163-16-1 4-nitro-benzenesulfonic acid 2-oxo-2-p-tolyl-ethyl ester 
• 619-41-0 4-(bromoacetyl)toluene 

Downstream Products

• 4079-54-3 2-hydroxy-1-p-tolyl-ethanone 
• 100-21-0 terephthalic acid 
• 52789-91-0 (5-bromobenzofuran-2-yl)(p-tolyl)methanone 
• 41967-43-5 (1-benzofuran-2-yl)(4-methylphenyl)methanone 
• 33429-09-3 (benzothiazol-2-yl)(p-tolyl)methanone 
• 945920-36-5 (5-chlorobenzo[d]thiazol-2-yl)(p-tolyl)methanone 
• 65964-60-5 2-para-tolylimidazo[1,2-a]pyridine 
• 108030-80-4 2-(4-methylphenyl)pyrazine 
• 142073-93-6 6-chloro-2-(4'-tolyl)imidazo<1,2-a>pyridine 
• 1644121-08-3 2,2,2-tris(4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazol-1-yl)-1-(p-tolyl)ethanone 
• 1644120-94-4 2,2,2-triazido-1-(4-methylphenyl)ethanone 
• 4209-24-9 p-methylphenacyl chloride 
• 1436865-47-2 3-(4-methylbenzoyl)indolizine-1-carbonitrile 

Relevant academic research and scientific papers

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed. In the presence of PhI(OAc)2 as promoter and under ambient conditions, the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding α-iodoketones without additional photocatalyst in good yields under sunlight irradiation. Meanwhile, the reactions of styrenes with tribromomethane and trichloromethane generate the desired α-bromoketones and α-chloroketones in high yields by using Ru(bpy)3Cl2 as a photocatalyst under blue LED (450–455 nm) irradiation.

Au(I)-Catalyzed Hydration of 1-Iodoalkynes Leading to α-Iodoketones

A catalytic protocol for the Au(I)-catalyzed hydration of 1-iodoalkynes is disclosed. The use of Au(I)–NHC catalyst enabled the straightforward synthesis of a variety of α-iodomethyl ketones in good to excellent yields. The utility of this simple method is further highlighted by showcasing iodination/hydration and hydration/oxidation sequential protocols leading to the construction of molecular complexity.

ANTIBACTERIAL/ANTIFUNGAL AGENT

PROBLEM TO BE SOLVED: To provide an antibacterial/antifungal agent that has an excellent antibacterial/antifungal activity. SOLUTION: The antibacterial/antifungal agent contains an iodine compound represented by the following general formula (1). In the g

Metal-Free, Oxidant-Free, and Controllable Graphene Oxide Catalyzed Direct Iodination of Arenes and Ketones

A direct, metal-free, and oxidant-free method for the graphene oxide (GO)-catalyzed iodination of arenes and ketones with iodine in a neutral medium was explored. This iodination protocol was performed by using a simple technique to avoid the use of external metal catalysts and oxidants and harsh acidic/basic reaction conditions. In addition, by this method the degree of iodination could be controlled, and the reaction was scalable and compatible with air. This strategy opens a new field for GO-catalyzed chemistry and provides an avenue for the convenient direct iodination of arenes and ketones.

Natural products as sources of new fungicides (V): Design and synthesis of acetophenone derivatives against phytopathogenic fungi in vitro and in vivo

A series of acetophenone derivatives (10a–10i, 11, 12a–12g, 13a–13g, 14a–14d and 15a–15l) were designed, synthesized and evaluated for antifungal activities in vitro and in vivo. The antifungal activities of 53 compounds were tested against several plant pathogens, and their structure–activity relationship was summarized. Compounds 10a–10f displayed better antifungal effects than two reference fungicides. Interestingly, the most potent compound 10d exhibited antifungal properties against Cytospora sp., Botrytis cinerea, Magnaporthe grisea, with IC50 values of 6.0–22.6 μg/mL, especially Cytospora sp. (IC50 = 6.0 μg/mL). In the in vivo antifungal assays, 10d displayed the significant protective efficacy of 55.3% to Botrytis cinerea and 73.1% to Cytospora sp. The findings indicated that 10d may act as a potential pesticide lead compound that merits further investigation.

Rapid and efficient one-pot microwave-assisted synthesis of 2-phenylimidazo[1,2-a]pyridines and 2-phenylimidazo[1,2-a]quinoline in water–PEG-400

An effective, expeditious, environmentally benign one-pot synthesis of 2-phenylimidazo[1,2-a]pyridines and 2-phenylimidazo[1,2-a]quinoline from easily available starting materials as aromatic carbonyl compound, 2-amino pyridine, succinamide, and in situ g

Expeditious one-pot multicomponent microwave-assisted green synthesis of substituted 2-phenyl Quinoxaline and 7-bromo-3-(4-ethylphenyl) pyrido[2,3-b]pyrazine in water–PEG and water–ethanol

An eco-friendly, expeditious one-pot multicomponent synthesis of substituted 2-phenyl quinoxaline and 7-bromo-3-(4-ethylphenyl) pyrido[2,3-b]pyrazine 4a–k in water–ethanol from easily available starting materials as acetophenone 1, succinamide 2, aromatic

First Catalyzed Hydration of Haloalkynes by a Recyclable Catalytic System

The hydration of haloalkynes to give α-halomethyl ketones was achieved based on a combination of a Cu(OAc)2 catalyst and a TFA (trifluoroacetic acid) promoter. This is the first synthesis of chloro/bromo/iodo methyl ketones through a hydration reaction catalyzed by a recyclable catalytic system. The catalytic system has a wide substrate scope and excellent chemoselectivity, and the procedure can also be scaled up.

In(OTf)3/acid co-catalyzed hydration of 1-haloalkynes to α-halomethyl ketones

A novel and efficient In(OTf)3and HOAc cooperatively catalyzed hydration of 1-haloalkynes is described. This method provides ready access to α-chloromethyl ketones, α-bromomethyl ketones and α-iodomethyl ketones in moderate to high yields from simple, inexpensive starting materials. A broad substrate scope is achieved, and the reaction is compatible with various functional groups, including alkoxy, trifluoromethyl, halide, hydroxyl, cyclohexyl, and heterocyclic groups.

Copper(I)-catalyzed oxidation of alkenes using molecular oxygen and hydroxylamines: Synthesis and reactivity of α-oxygenated ketones

The copper(I)-catalyzed oxidation of alkenes with molecular oxygen and N-hydroxyphthalimide (NHPI) or N-hydroxybenzotriazole (HOBt) provided α-oxygenated ketones. The reaction proceeded under a balloon of O2 at room temperature to furnish the dioxygenated products in 50-90% yield. These compounds, particularly the HOBt derivatives, can be further functionalized with phosphorus, nitrogen, and sulfur nucleophiles to give synthetically useful products.