41968-98-3

Upstream product

• 108-86-1 bromobenzene 
• 95104-21-5 2-chloroquinoline-3-carbonitrile 
• 94429-06-8 2-chloro-3-cyano-4-phenylquinoline 
• 101617-85-0 2-chloro-3-cyano-4-phenyl-1,4-dihydroquinoline 
• 288-14-2 ISOXAZOLE 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 538-51-2 benzylidene phenylamine 
• 107-13-1 acrylonitrile 
• 101617-92-9 3-cyano-2-methylthioquinoline 
• 69513-35-5 3-Cyanoquinoline-2(1H)-thione 
• 101617-67-8 3-cyano-2-methylthio-4-phenylquinoline 

Relevant academic research and scientific papers

Ru(III)-catalyzed construction of variously substituted quinolines from 2-aminoaromatic aldehydes (ketones) and isoxazoles: Isoxazoles as cyclization reagent and cyano sources

A Ru(Ⅲ)-catalyzed annulation reaction of 2-aminoaromatic aldehydes (ketones) and isoxazoles to afford diverse 3-cyanoquinolines has been developed. Notably, isoxazole acted as a cyclization reagent and nontoxic cyano source via N-O bond cleavage and fragm

3-nitrile quinoline derivative and preparation method thereof

The invention discloses a 3-nitrile quinoline derivative. The structural formula of the 3-nitrile quinoline derivative is shown as a formula I, wherein R1 is hydrogen, alkyl or aryl; R2-R5 are respectively and independently hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, ester group, hydroxyl or amino; and R6 is hydrogen, alkyl, ester group, aryl or substituted aryl. According to the 3-nitrile quinoline derivative provided by the invention, R1-R6 sites can be connected with various substituent groups, and the 3-nitrile quinoline derivative is an organic synthesis intermediate with wide application and has important application value in the fields of medicines and organic synthesis. The invention further provides the preparation method of the 3-nitrile quinoline derivative, the preparation method can be carried out under the air condition, the reaction condition is mild and easy to control, the used raw materials are easy to obtain, toxic nitrile compounds are not needed to serve as nitrile groups sources, the substrate application range is wide, the reaction conversion rate is high, high selectivity and yield can be obtained within short time, and the method is simple in post-treatment, green, environment-friendly and suitable for large-scale industrial production.

Acrylonitrile and substituted phenyl Schiff base reaction of the new method for synthesizing substituted quinoline

The invention relates to a new method for synthesis of substituted quinoline through reaction of acrylonitrile and substituted phenyl Schiff base. The method includes: adding substituted phenyl Schiff base and acrylonitrile in a mole ratio of 1:1.1 into a reaction container containing glacial acetic acid, stirring them uniformly, conducting heating and heat preservation on the reaction solution till the end of the reaction, evaporating the acetic acid, and then subjecting the residue to thin layer chromatography so as to obtain the substituted quinoline. The method provided in the invention solves the defects of strict requirements for substrates, inconvenient product separation and purification, applicability to preparation of only special structure quinoline derivatives, difficult separation and recovery of transition metal catalysts and heavy metal drug residue and the like in previous methods. The method involved in the invention has the advantages of simple operation, molecular economy, low energy consumption, and highest product yield.

Palladium(ii)-catalysed regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstituted pyrroles from alkenes via anti-Markovnikov selectivity

A novel strategy has been identified for the regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstituted pyrroles from simple alkenes via anti-Markovnikov selectivity under palladium catalysis. The salient features are synthesis of two different heterocycles, readily available starting materials, broad substrate scope, moderate to good yields and use of molecular oxygen as a terminal oxidant.

Grignard Reaction of 2-Substituted-3-Cyanoquinolines

Grignard reactions of 2-morpholino and 2-methylthio-3-cyanoquinoline, 2-chloro-3-cyanoquinoline, 2-chloro-3-cyano-6-methoxyquinoline and 2-chloro-3-cyano-7-methylquinoline with alkyl or aryl magnesium halides have been studied.It was found that 2-morpholi