41972-62-7Relevant academic research and scientific papers
Histone lysine methyltransferase NSD2 inhibiting small-molecule compound and application thereof
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Paragraph 0084-0089, (2019/05/22)
The invention belongs to the field of chemical medicine and particularly relates to a histone lysine methyltransferase NSD2 inhibiting small-molecule compound. A general formula of the small-moleculecompound is as shown in the specification. According to
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors
Liu, Feng,Li, Fengling,Ma, Anqi,Dobrovetsky, Elena,Dong, Aiping,Gao, Cen,Korboukh, Ilia,Liu, Jing,Smil, David,Brown, Peter J.,Frye, Stephen V.,Arrowsmith, Cheryl H.,Schapira, Matthieu,Vedadi, Masoud,Jin, Jian
, p. 2110 - 2124 (2013/05/08)
Protein arginine methyltransferases (PRMTs) play an important role in diverse biological processes. Among the nine known human PRMTs, PRMT3 has been implicated in ribosomal biosynthesis via asymmetric dimethylation of the 40S ribosomal protein S2 and in c
SELECTIVE ANDROGEN RECEPTOR MODULATORS
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Page/Page column 44-45, (2012/04/23)
This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.
