42006-92-8

Upstream product

• 1126-46-1 Methyl 4-chlorobenzoate 
• 74-11-3 para-chlorobenzoic acid 
• 7335-27-5 ethyl 4-chlorobenzoate 

Downstream Products

• 114738-21-5 α,α-dideuterio-4-chlorobenzyl chloride 
• 1517-47-1 p-chlorobenzaldehyde-d1 
• 1251555-24-4 1-(bromomethyl-d2)-4-chlorobenzene 
• 114738-22-6 C₂₂H₂₀⁽²⁾H₄Cl₂O₅ 

Relevant academic research and scientific papers

Reductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D 2O as Deuterium Source

α,α-Dideuterio benzyl alcohols are important building blocks for the synthesis of deuterium-labeled medicines and agrochemicals. We have developed the first general single-electron transfer reductive deuteration of readily commercially available aromatic

An α, α - dideuterium substituted benzyl alcohol compound. Deuterated drug and method for reducing deuteration of benzoate compound

The invention relates to a method. Α, α-deuterated benzyl alcohol compound and preparation thereofΑ, αThe method for reducing and deuteration - dideuterium-substituted benzyl alcohol compounds is characterized in that the benzoate compound represented by

DEUTERATED PITOLISANT

This invention also provides compound of Formula (I) including pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable carrier. This invention also provides the use of such compounds and compositions in methods o

One-Pot Synthesis of Quinazolin-4(3H)-ones through Anodic Oxidation and the Related Mechanistic Studies

A metal-free and oxidant-free method for the one-pot preparation of quinazolin-4(3H)-ones enabled by electrochemical oxidation is described. Together with 2-aminobenzamides, a variety of aldehydes were successfully applied to an acid-catalyzed annulation and direct anodic oxidation cascade, affording structurally diverse quinazoline-4(3H)-ones in good to excellent yields. Additionally, certain alcohols can be directly applied instead of the corresponding aldehydes to achieve the same final products with the assistance of an electrolysis mediator (TEMPO). The reaction mechanism was carefully examined and the results strongly suggest that the direct and indirect oxidation go through different pathways. As an efficient and environmentally friendly access to a broad range of quinazolin-4(3H)-ones, the synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive mackinazolinone and truncated erlotinib. (Figure presented.).

BENZIMIDAZOLE MODULATORS OF H1 RECEPTOR AND/OR NS4B PROTEIN ACTIVITY

The present invention relates to new benzimidazole modulators of H1 receptor activity and/or inhibitors of NS4B protein activity, pharmaceutical compositions thereof, and methods of use thereof formula (I).

DEUTERIUM MODIFIED BENZIMIDAZOLES

This invention relates to derivatives of 1-(p-chIorobenzyI)-2-(1-pyrrolidinylmethyl)benzimidazole according to Formula I wherein at least one Y is deuterium described herein and pharmaceutically acceptable salts thereof. This invention also provides compo

Aromatic oxidative decompositions of copper Schiff base complexes

Copper Schiff base complexes used in enantioselective aziridination reactions were shown to possess a proclivity for aromatic oxidative coupling reactions.

Unusual 1,5-Hydride Shifts in Lewis Acid Mediated Reactions of Benzylated Sugars. Synthesis of 3-Alkylisochroman Derivatives

Tin(IV) chloride mediated reactions of methyl 3,5-di-O-(4-chlorobenzyl)-2-O-(3-methoxybenzyl)-D-arabino- and -D-xylofuranosides 5 and 13 afforded unexpectedly, in one step, 3-alkyl-7-methoxyisochroman derivatives 7 and 14, respectively.These products are formed, most probably, by way of a complex process involving the intramolecular Friedel-Crafts alkylation of the activated benzyl group at O-2, leading to an internal aryl C-furanoside (e.g. 6), followed by an in situ reductive opening of the tetrahydrofuranyl ring of the intermediate C-furanoside.An experiment with a deuterium-labeled substrate demonstrated that this reductive step occurred by way of a stereospecific, tin(IV) chloride promoted 1,5 shift of a hydride ion from the 4-chlorobenzyl substituent at O-3 to the "anomeric" position of the C-furanoside, with retention of configuration at the migration terminus, and formation (after aqueous processing) of 4-chlorobenzaldehyde as a byproduct.This process provides a convenient methodology for the synthesis of enantiomerically pure isochroman derivatives from readily available carbohydrate precursors.

Isotope effects in nucleophilic substitution reactions. IV. The effect of changing a substituent at the α carbon on the structure os SN2 transition states

Kinetic studies, secondary α-deuterium kinetic isotope effects, primary chlorine kinetic isotope effects (1), Hammett ρ values determined by changing the substituent in the nucleophile, and activation parameters have been used to determine the detailed (relative) structures of the transition states for the S2 reactions between para-substituted benzyl chlorides and thiophenoxide ion.A rationale for the U-shaped Hammett ρ plots observed when para-substituted benzyl compounds react with negatively charged nucleophiles is also presented.