420102-99-4

Upstream product

• 7596-74-9 3-(1H-benz[d]imidazol-2-yl)aniline 
• 1711-05-3 m-anisoyl chloride 
• 121-90-4 m-nitrobenzoic acid chloride 
• 95-54-5 1,2-diamino-benzene 
• 586-38-9 3-Methoxybenzoic acid 
• 15456-62-9 2-(3-nitrophenyl)-1H-benzimidazole 
• 65953-23-3 3-nitro-N-[2-[(3-nitrobenzoyl)amino]phenyl]benzamide 

Relevant academic research and scientific papers

Benzimidazole derivative and application thereof

The invention relates to the field of medicinal chemistry, in particular to a 3-(1H-benzo [d] imidazole-2-yl) aniline derivative with alpha-glucosidase inhibition activity, and the structural generalformula of the derivative is shown in the specification.

Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae

Chlamydia pneumoniae is an intracellular bacterium that responds poorly to antibiotic treatment. Insufficient antibiotic usage leads to chronic infection, which is linked to disease processes of asthma, atherosclerosis, and Alzheimer's disease. The Chlamydia research lacks genetic tools exploited by other antimicrobial research, and thus other approaches to drug discovery must be applied. A set of 2-arylbenzimidazoles was designed based on our earlier findings, and 33 derivatives were synthesized. Derivatives were assayed against C. pneumoniae strain CWL-029 in an acute infection model using TR-FIA method at a concentration of 10 μM, and the effects of the derivatives on the host cell viability were evaluated at the same concentration. Fourteen compounds showed at least 80% inhibition, with only minor changes in host cell viability. Nine most potential compounds were evaluated using immunofluorescence microscopy on two different strains of C. pneumoniae CWL-029 and CV-6. The N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide (42) had minimal inhibitory concentration (MIC) of 10 μM against CWL-029 and 6.3 μM against the clinical strain CV-6. This study shows the high antichlamydial potential of 2-arylbenzimidazoles, which also seem to have good characteristics for lead compounds.