420118-92-9

Upstream product

• 420118-99-6 (E)-(S)-4-tert-Butoxycarbonylamino-5-[4-(2,6-dichloro-benzyloxy)-phenyl]-pent-2-enoic acid methyl ester 
• 18942-49-9 Boc-D-Phe-OH 
• 176755-26-3 (E)-(S)-4-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-5-[4-(2,6-dichloro-benzyloxy)-phenyl]-pent-2-enoic acid methyl ester 
• 420119-00-2 (E)-(S)-4-Amino-5-[4-(2,6-dichloro-benzyloxy)-phenyl]-pent-2-enoic acid methyl ester 
• 143961-89-1 Boc-Tyr(Cl₂-Bzl)-H 

Downstream Products

• 176755-29-6 C₅₄H₆₉Cl₂N₉O₁₂ 
• 176755-20-7 C₅₁H₅₇Cl₂N₇O₁₀ 
• 129033-05-2 cyclotheonamide B 
• 420118-91-8 {(2S,3S,6R)-6-Benzyl-3-[4-(2,6-dichloro-benzyloxy)-benzyl]-5-oxo-piperazin-2-yl}-acetic acid methyl ester 
• 176755-27-4 (4S,5R)-4-(3-Benzyloxycarbonylamino-propyl)-5-((R)-1-{(E)-(S)-1-[4-(2,6-dichloro-benzyloxy)-benzyl]-3-methoxycarbonyl-allylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

An efficient synthesis of the piperazinone fragment of pseudotheonamide A1 via a stereoselective intramolecular Michael ring closure

The stereoselective intramolecular Michael ring closure of the dipeptide efficiently gives the piperazinone fragment of pseudotheonamide A1, a serine protease inhibitor from the marine sponge Theonella swinhoei.

A new synthesis of cyclotheonamide B via guanidination of ornithine

A macrocyclic thrombin inhibitor, cyclotheonamide B (1, R = Ac) was synthesized via a new approach: guanidination of the ornithine-containing macrocyclic peptide (2). In comparison of various coupling reagents, pentafluorophenyl diphenylphosphinate (FDPP) gave the macrocyclic peptide (2) in good yield, and the configuration of the amino acid residue has been revealed to be important for the macrolactamization.