420137-14-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(Benzyloxy)pyrrolidine is used as a synthetic intermediate for the development of new drugs and therapeutic compounds. Its benzyl group provides a stable platform that can be modified to create a variety of pharmaceutically relevant molecules, contributing to the advancement of medicinal chemistry.
Used in Academic Research:
In the realm of academic research, 3-(Benzyloxy)pyrrolidine serves as a subject for the study of organic chemistry and chemical synthesis methods. Its unique properties and reactivity make it an interesting compound for exploring new synthetic pathways and understanding reaction mechanisms in organic chemistry.

Upstream product

• 192942-82-8 4-benzyloxy-pyrrolidin-2-one 
• 127342-21-6 tert-butyl 3-(benzyloxy)pyrrolidine-1-carboxylate 
• 100-51-6 benzyl alcohol 
• 769961-91-3 N-(2-benzyloxy-ethyl)-2-diazo-N-(1-methyl-1-phenyl-ethyl)-acetamide 
• 769961-92-4 4-benzyloxy-1-(1-methyl-1-phenyl-ethyl)-pyrrolidin-2-one 
• 769961-90-2 (2-benzyloxy-ethyl)-(1-methyl-1-phenyl-ethyl)-amine 
• 1462-37-9 bromoethyl-2-benzyl ether 

Relevant academic research and scientific papers

tert-Butyl 3-Diazo-2-oxopyrrolidine-1-carboxylate – A New Reagent for Introduction of the 2-Oxopyrrolidin-3-yl Motif via RhII-Catalyzed X–H Insertion Reactions

tert-Butyl 3-diazo-2-oxopyrrolidine-1-carboxylate synthesized on multigram scale has been employed to introduce a privileged NH-2-pyrrolidone moiety via oxygen, sulfur and nitrogen atom to partner molecules via RhII-catalyzed X–H insertion followed by Boc group removal. Further manipulation of pyrrolidine moiety has been exemplified.

2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS

A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof (I) wherein R2 represents a hydrogen or the like; R3 represents methyl group or the like; R20 represents a halogen atom or the like; q represents an integer of 0 to 3; Z represent nitrogen atom, CH, or the like; R4 represents hydrogen or the like; R5 represents hydrogen or the like; R6 represents a substituted alkyloxy and the like; p represents an integer of 0 to 3; X represents bond, CH2, oxygen atom, NH, or the like; any one or more of R5 and R6, R5 and R4, R6 and R4, X and R5, X and R4, X and R6, and R6 and R6 may combine to each other to form a ring, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

Cumyl: A better N-protecting group of α-diazo acetamides for intramolecular C-H insertion reaction and its application in the synthesis of pregabalin and 3-benzyloxy pyrrolidine

Via intramolecular C-H insertion of N-cumyl α-diazo acetamides, γ-lactams were efficiently synthesized with excellent regioselectivity. A concise route for the preparation of pregabalin (79% overall yield) and 3-benzyloxy pyrrolidine (21% overall yield) were reported.