42019-50-1Relevant academic research and scientific papers
Mild Pd-catalyzed aminocarbonylation of (hetero)aryl bromides with a palladacycle precatalyst
Friis, Stig D.,Skrydstrup, Troels,Buchwald, Stephen L.
, p. 4296 - 4299 (2014)
A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading and only a slight excess of CO. Some products are unattainable by traditional carbonylative coupling.
