Mild Pd-catalyzed aminocarbonylation of (hetero)aryl bromides with a palladacycle precatalyst

Article abstract of DOI:10.1021/ol502014b

A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading and only a slight excess of CO. Some products are unattainable by traditional carbonylative coupling.

Full text of DOI:10.1021/ol502014b

Letter
pubs.acs.org/OrgLett
Open Access on 08/04/2015
Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides
with a Palladacycle Precatalyst
Stig D. Friis,†,‡ Troels Skrydstrup,*,† and Stephen L. Buchwald*,‡
†Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry,
Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark
‡Department of Chemistry, Massachusetts Institute of Technology, Room 18-490, Cambridge, Massachusetts 02139, United States
S
* Supporting Information
ABSTRACT: A palladacyclic precatalyst is employed to cleanly
generate a highly active XantPhos-ligated Pd-catalyst. Its use in
low temperature aminocarbonylations of (hetero)aryl bromides
provides access to a range of challenging products in good to
excellent yields with low catalyst loading and only a slight excess
of CO. Some products are unattainable by traditional carbon-
ylative coupling.
(hetero)aryl bromides usually must be conducted at elevated
eterocycles are an important constituent in many
Hpharmaceuticals. Transition metal catalysis plays a key temperatures.6 The more reactive (hetero)aryl iodides can in
1
some cases be utilized, but only a narrow selection of such iodides
are available due to their limited stability.7 The literature also
reveals a lack of good procedures for the conversion of more
difficult (hetero)aryl bromides, including 3-bromoindole, 3-
bromopyridazine, 2-bromothiazole, or 2-bromobenzimidazole,
into the corresponding amides.
Herein, we describe the low temperature conversion of aryl
and heteroaryl bromides to their corresponding secondary and
tertiary amides enabled by the use of a palladacycle precatalyst.
The increased activity of the catalyst generated from this
precatalyst provides easy access to products, which are otherwise
inaccessible via Pd-catalyzed aminocarbonylation or provide low
yields due to significant unproductive side reactions such as SNAr
or addition to/substitution of other functional groups in the
molecule.
role in the selective functionalization of heteroaromatic systems.
Yet, many metal-catalyzed transformations suffer from the metal
coordinating ability of heterocycles, resulting either in byproduct
formation or inhibition of catalytic turnover.2 In many instances,
specialized reaction conditions or catalyst systems are needed in
order to provide reasonable yields of the desired products.3
Amides represent a ubiquitous functional group in pharma-
ceutically relevant compounds and are frequently attached to a
heteroaryl core (Figure 1). Although many routes rely on the use
of carboxylic acid starting materials,4 an appealing approach to
amides relies on a three-component Pd-catalyzed coupling of a
(hetero)aryl halide with an amine and CO.5 While this
transformation has been widely used, limitations remain with
substrates bearing sensitive functional groups, as the coupling of
In recent years, palladium precatalysts have received significant
attention because of their ability to selectively generate the
ligated Pd(0)-complex with only minimal coordinating by-
products.8 The employment of these precatalysts, with their ease
of use, significantly enhances the catalytic activity, compared to
catalysts generated from, e.g., Pd(dba)2 or Pd(OAc)2.9 We
therefore envisioned that a catalyst generated from the
palladacycle precatalyst 1 (Figure 2) could provide the additional
activity needed, in order to carbonylate more difficult heteroaryl
bromides, as well as substrates susceptible to SNAr-type
reactions. The N-methyl-2-aminobiphenyl based precatalyst 1
was chosen over the simpler 2-aminobiphenyl based precatalyst
Figure 1. Selection of FDA-approved drugs containing heteroaryl
amides.
Received: July 10, 2014
Published: August 4, 2014
© 2014 American Chemical Society
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Organic Letters
Letter
for further optimization as it gave a slightly higher isolated yield
and is easily removed under vacuum (Table 1, entry 7); dioxane
is the solvent of choice (Table 1, entries 8−10). Increasing the
concentration to 0.50 M while lowering the catalyst loading to
2.0 mol % with 2.0 equiv of nucleophile and base did not
significantly affect the isolated yield (Table 1, entry 11).
With conditions for a low temperature aminocarbonylation at
hand enabled by the use of 1f, we set out to probe the scope of
this protocol as shown in Scheme 1. The excellent yields of 4a
Scheme 1. Low Temperature Aminocarbonylation of
(Hetero)Aryl Bromides with Morpholine; Isolated Yields and
Average of Two Runs, (Het)Ar−Br (1.0 mmol), 0.50 M
Figure 2. Palladacycle precatalyst and phosphine ligands examined for
low temperature aminocarbonylations.
to eliminate the potential reaction of the carbazole byproduct,
which would cause reduced yields and possibly complicate
purification of the products.8f
Applying our COware two-chamber system and a solid
silacarboxylic acid CO precursor, to avoid the handling of the
toxic gas, we set out to develop conditions for this trans-
formation.10 As illustrated in Table 1, the unactivated aryl
Table 1. Optimization of Low Temperature
Aminocarbonylation Employing a Palladacycle Precatalyst
a
b
entry
catalyst
solvent
base
yield of 3a [%]
1
2
3
4
1a−d
1e
1f
dioxane
dioxane
dioxane
dioxane
dioxane
dioxane
dioxane
MeCN
PhMe
Cy2NMe
Cy2NMe
Cy2NMe
Cy2NMe
DBU
trace
16
99 (92)
0
1g
1f
c
5
6
6
1f
K2CO3
Et3N
97
7
1f
99 (97)
24
8
1f
Et3N
9
1f
Et3N
trace
21
10
1f
CPME
Et3N
d
11
1f
dioxane
Et3N
99 (93)
a
b
2 (0.25 mmol), 0.25 M. GC yield, isolated yield in parentheses.
c
d
Yield of 3b: 19% 2 (1.0 mmol), 1f (2 mol %), Et3N (2.0 mmol), and
morpholine (2.0 mmol) in dioxane (2.0 mL).
a
b
c
d
bromide 2 was selected for the optimization studies. Poor catalyst
stability was observed when starting with the precatalysts 1a−d
bearing monodentate ligands or dccp [1,3-bis-
(dicyclohexylphosphino)propane], and only trace conversion
of 2 was observed. With precatalyst 1e based on the ligand dppf
[1,1′-bis(diphenylphosphino)ferrocene], conversion to product
was observed, but in low yield. In contrast, with the precatalyst
based on XantPhos 1f,5d,11 full conversion of 2 was seen and
amide 3a was isolated in a 92% yield, when the reaction was
carried out at a temperature of only 45 °C. Decreasing the
temperature further resulted in incomplete conversion of 2.
The nature of the base included in the reaction was also crucial.
Employing 1f with the stronger base DBU (Table 1, entry 5)
reduced the yield of the desired product significantly and instead
provided the double carbonylated product 3b in a 19% GC
yield.12 Triethylamine proved to be the ideal base and was chosen
Used as HCl salt, Et3N (3.0 mmol). 80 °C. 65 °C. MePh2SiCO2H
e f
(1.0 mmol), KF (1.0 mmol). 2,4-Dibromothiazole (0.5 mmol). 0.25
M.
and 4b demonstrate that electron-poor and electron-rich aryl
bromides can undergo efficient coupling using this catalytic
system. Turning to the heteroaromatic bromides, 5-bromoiso-
quinoline was first coupled to afford 4c in a 99% isolated yield.
Having the bromide situated on a heteroaryl ring did not affect
the yield, as 4d was isolated in 98% yield, while 87% of the 2,6-
difunctionalized pyridine 4e was realized. The presence of an
additional nitrogen in the ring was also inconsequential as 5-
bromopyrimidine could be converted to 4g in 93% yield.13
The indole ring system represents a privileged structure in
drug discovery, and it is well-known that reaction of substrates in
which the nitrogen is unprotected can be problematic.2b,3b,14
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This tendency was also observed in this transformation as the
carbonylation of unprotected 5-bromoindole must be conducted
at 80 °C to provide 4h in a satisfactory yield. On the other hand,
the corresponding N-Boc substrate was carbonylated to provide
an excellent yield of 4i at 45 °C. While no observable conversion
of 3-bromo-N-Boc-indole was seen at this temperature, at 80 °C
the desired heteroaryl amide 4j was produced in a 87% isolated
yield. The more activated N-Boc-3-bromoindazole coupled well
to afford a 79% yield of amide 4k.
Scheme 2. Low Temperature Aminocarbonylation of 2-
Bromopyridine and a Selection of Amines; Isolated Yields and
Average of Two Runs, 2-Bromopyridine (1.0 mmol), 0.50 M
The aminocarbonylation of a bromopyridazine and a
bromocinnoline also proceeded efficiently, leading to products
4l and 4m in good yields, although a slightly higher reaction
temperature was necessary to realize a good yield of 4m, possibly
due to the presence of an ortho substituent in the substrate. The
allyl-protected 2-bromobenzimidazole also coupled nicely at low
temperature to give 4n in an 82% isolated yield.
The use of bromothiazoles as substrates was next examined. In
particular, these substrates are susceptible to SNAr with the amine
nucleophile.15 Subjecting 2-bromothiazole to the optimized
reaction conditions furnished an 86% yield of product 4o, with
no observation of product arising from SNAr. Applying identical
conditions on the 2,4-dibromothiazole resulted in only a 73%
yield of the desired product 4p. The slightly lower yield was due
to a second carbonylation at C4 with the slight excess of CO.
Nevertheless, the yield was improved to 85% by lowering the
amount of the silacarboxylic acid to 1.0 equiv, thereby preventing
the coupling at the more electron-rich 4-position. On the other
hand, employing 2.4 equiv of CO provided smoothly the
difunctionalized thiazole 4q in excellent yield, emphasizing the
importance of being able to accurately control the quantity of CO
utilized in the reaction.
a
b
c
d
65 °C. Et3N (4.0 mmol). Used as HCl ammonium salt. 0.25 M.
e
RR′NH (1.2 mmol), Et3N (3.2 mmol).
by the high yield formation of 5h. However, introducing a free
aniline did have a slightly detrimental effect as 5i could only be
isolated in a 72% yield.
In order to demonstrate the superiority of the palladacycle
precatalyst, it was compared to a selection of traditional Pd(0)
and Pd(II) sources reported in the literature (Figure 3).5e,17 The
Three different thiophenes were tested, providing both amide
4r and 4s in excellent yields. However, when moving the bromide
to the more electron-rich C3-position, a slight increase in
temperature was required for the reaction to go to completion,
providing 4t in 96% yield. The products 4u and 4v both contain
functional groups that allow for easy postcoupling modification
via SN2 substitution of the primary alkyl chloride in 4u or acyl
substitution of the thioester displayed by 4v. These functional
groups, however, also make them sensitive substrates, which may
not be tolerated under traditional aminocarbonylation con-
ditions at elevated temperatures. However, applying this more
active catalytic system at 45 °C provided the desired products in
good yield.
Next, variations of the amine nucleophile were examined in the
aminocarbonylation of 2-bromopyridine. Using a volatile,
sterically hindered primary amine, tert-butylamine, did not
have a profound effect on the efficiency of the reaction, as the
product 5a was isolated in 77% yield (Scheme 2). On the other
hand, coupling with the more sterically hindered diisopropyl-
amine proved to be slightly more sluggish, furnishing 55% of the
desired amide 5b at 65 °C. This increased temperature was also
necessary to achieve full conversion with tritylamine as the
nucleophile, giving 5c, which can easily be converted into the
primary amide.16 3-Chloropropylamine is commercially available
as the corresponding hydrochloride, possibly due to potential
polymerization or intramolecular cyclization. Additional base
was consequently added for its reaction, and after 16 h at 45 °C,
product 5d could be isolated in a 92% yield, with no signs of SN2
substitution on the alkyl chloride.
Figure 3. Comparison of palladacycle precatalyst 1f with traditional Pd
sources at different temperatures. GC yields, 2 (1.0 mmol), 0.50 M.
conversion of aryl bromide 2 into amide 3a was examined at six
temperatures ranging from 30 to 80 °C, applying either
precatalyst 1f or Pd(OAc)2, Pd(dba)2, or Pd(COD)Cl2 in
combination with an equimolar amount of XantPhos. Whereas
the traditional Pd sources did not show any catalytic turnover at
temperatures lower than 60 °C and produced synthetically useful
yields only at 80 °C, precatalyst 1f furnished amide 3a in good
yield at 40 °C, while providing the amide quantitatively at 50 °C,
emphasizing that a more active catalyst for the amino-
carbonylation is generated from this palladacycle precatalyst.
In conclusion, the use of a palladacycle precatalyst has been
shown to have a significant rate-enhancing effect on the
aminocarbonylation relative to traditional catalytic systems.
The low temperature at which this carbonylative coupling is
conducted provides access to a range of products that are
otherwise not easily accessible. An array of electron-rich and
electron-poor aryl and heteroaryl bromides has, despite their
sensitive nature, been coupled in good to excellent yields.
Moreover, both tertiary and secondary amides have been
synthesized, while formal access to primary amides has been
Amines carrying an additional nucleophile were also examined.
For example, ethanolamine was used for the synthesis of 5e in
95% yield. The presence of a free phenol is also tolerated as seen
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Letter
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ASSOCIATED CONTENT
* Supporting Information
■
S
Experimental procedures and spectroscopic data. This material is
available free of charge via the Internet at http://pubs.acs.org.
AUTHOR INFORMATION
Corresponding Authors
■
*E-mail: ts@chem.au.dk.
*E-mail: sbuchwal@mit.edu.
(11) (a) Kranenburg, M.; van der Burgt, Y. E. M.; Kamer, P. C. J.; van
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Dierkes, P. Chem. Rev. 2000, 100, 2741. (c) Other XantPhos-like ligands
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(12) (a) This is noteworthy because the α-ketoamides are generally
accessed via low temperature double carbonylation of the corresponding
aryl iodide. Unfortunately, this reaction could not be optimized to
produce 3b in a synthetically useful yield. (b) Iizuka, M.; Kondo, Y.
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(13) Attempts to couple the 2-bromopyrimidine cleanly afforded a 1:3
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Notes
The authors declare the following competing financial
interest(s): MIT holds or has filed patents on some of the
ligands and precatalysts used in this work, for which S.L.B.
receives royalty payments. T.S. is a co-owner of SyTracks a/s.
ACKNOWLEDGMENTS
■
Research reported in this publication was supported by the
National Institutes of Health under award number GM46059.
The content is solely the responsibility of the authors and does
not necessarily represent the official views of the National
Institutes of Health. We also thank the Danish National Research
Foundation (Grant number DNRF59), the Villum Foundation,
the Danish Council for Independent Research: Technology and
Production Sciences for generous financial support of this work.
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