42026-07-3Relevant academic research and scientific papers
REACTION OF CYCLIC THIOUREAS WITH CHLOROACYLPIPERAZINES
Groszkowski, S.,Krezhel, I.,Kozycka, L.
, p. 672 - 675 (1984)
S-Alkylation products are formed in the reaction of tetrahydropyrimidine-2-thione and hexahydro-1,3-diazepine-2-thione with chloroacylpiperazines in dimethylformamide at room temperature; dihydrothiazolopyrimidine and tetrahydrothiazolo-diazepine systems are obtained in refluxing ethanol.It is shown that the S-alkyl derivatives are very readily converted to condensed systems.
