42027-43-0

Basic information

• Product Name: 2-{[(E)-(4-chlorophenyl)methylidene]amino}benzoic acid
• CAS NO: 42027-43-0
• Molecular Formula: C₁₄H₁₀ClNO₂
• Molecular Weight: 259.6877
• Mol File: 42027-43-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 462.4°C at 760 mmHg
• Flash Point: 233.4°C
• Density: 1.23g/cm³
• Vapor Pressure: 2.4E-09mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-{[(E)-(4-chlorophenyl)methylidene]amino}benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(E)-(4-chlorophenyl)methylidene]amino}benzoic acid(42027-43-0)
• EPA Substance Registry System: 2-{[(E)-(4-chlorophenyl)methylidene]amino}benzoic acid(42027-43-0)

Safety Data

• Hazardous Substances Data: 42027-43-0(Hazardous Substances Data)

Usage

Physical state

Yellow solid

Common uses

Pharmaceutical research and drug development

Potential properties

Anti-inflammatory and analgesic

Possible applications

Treatment of various inflammatory conditions

Usage

Building block for the synthesis of other biologically active compounds

Significance

Promising pharmacological properties and interesting target for further investigation in medicinal chemistry.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 118-92-3 anthranilic acid 

Downstream Products

• 1305341-85-8 C₂₀H₁₃BrClN₃O₂ 
• 1305341-86-9 C₂₀H₁₃ClN₄O₄ 
• 1305341-84-7 C₂₀H₁₃Cl₂N₃O₂ 
• 18600-52-7 2-(4-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 86705-77-3 2-(2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-(5-propyl-[1,3,4]thiadiazol-2-yl)-3H-quinazolin-4-one 
• 86705-70-6 2-(2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-(5-ethyl-[1,3,4]thiadiazol-2-yl)-3H-quinazolin-4-one 
• 86705-63-7 2-(2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-(5-methyl-[1,3,4]thiadiazol-2-yl)-3H-quinazolin-4-one 
• 86705-62-6 2-(2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-[1,3,4]thiadiazol-2-yl-3H-quinazolin-4-one 
• 86705-48-8 2-(2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-benzo[d][1,3]oxazin-4-one 
• 77810-67-4 2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-benzoyl chloride 

Relevant articles and documents

Phl(OAc)2-mediated one-pot synthesis of benzoxazinones from anthranilic acids and aromatic aldehydes

A novel way to synthesise 2-aryl-4H-benzo[d][1,3]oxazin-4-ones has been developed by the cyclisation of Schiff bases with (diacetoxyiodo)benzene. The salient features of this new protocol which starts from an anthranilic acid and an aromatic aldehyde, are

Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents

Diazotization of N-benzylidene anthranilic acids 1a-1n at pH 9 yielded N-[α-(phenylazo) benzylidene] anthranilic acids 2a-2n and at pH 3 yielded N-benzylidene-5-(phenylazo) anthranilic acids 3a-3n. When compounds 3a-3n were treated with thioglycolic/thiolactic acid in the presence of anhydrous ZnCl 2, 2-(4-oxo-2-phenylthiazolidin-3-yl)-5-(phenylazo) benzoic acids 4a-4n were afforded. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities and were compared with standard drugs, aspirin and phenylbutazone. Out of the compounds studied, the most active compound 4n showed more potent activity than the standard drugs at all doses tested.