42027-64-5

Usage

Physical state

Yellow crystalline solid

Classification

Amino acid

Structural features

Contains a benzene ring and a carboxylic acid group

Uses

Primarily used as an intermediate in the synthesis of other compounds, utilized in organic synthesis and pharmaceutical research

Potential biological activities

Antimicrobial and antitumor properties.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 118-92-3 anthranilic acid 

Downstream Products

• 119541-89-8 Cu(C₁₄H₉N₂O₄)Cl(H₂O) 
• 87881-84-3 {(OOC(C₆H₄)NCH(C₆H₄)NO₂)2(H₂O)2UO₂} 
• 119541-92-3 Cu(C₂₃H₁₆N₃O₄)Cl(H₂O) 
• 119541-90-1 Cu(C₁₇H₁₃N₄O₄)Cl(H₂O) 
• 119541-91-2 Cu(C₂₀H₁₆N₃O₄)Cl(H₂O) 
• 1305341-89-2 C₂₀H₁₃N₅O₆ 
• 1305341-88-1 C₂₀H₁₃BrN₄O₄ 
• 1305341-90-5 C₂₀H₁₂ClFN₄O₄ 
• 86705-61-5 2-(2-{[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-[1,3,4]thiadiazol-2-yl-3H-quinazolin-4-one 
• 86705-54-6 2-(2-{[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-benzo[d][1,3]oxazin-4-one 
• 654649-23-7 5-(p-chlorophenylazo)-N-(p-nitrobenzylidene)anthranilic acid 
• 82673-62-9 2-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-benzoyl chloride 
• 555-16-8 4-nitrobenzaldehdye 
• 118-92-3 anthranilic acid 

Relevant academic research and scientific papers

Water-soluble organocatalysts for hydrazone and oxime formation

The formation of oximes and hydrazones is widely used in chemistry and biology as a molecular conjugation strategy for achieving ligation, attachment, and bioconjugation. However, the relatively slow rate of reaction has hindered its utility. Here, we rep

Synthesis, characterization and use of Schiff bases as fluorimetric analytical reagents (part II)

Many Schiff bases were prepared by condensation reaction of certain aromatic amines with aromatic aldehydes derivatives and then the fluorescence properties of these Schiff bases were examined in acidic and basic media. It is shown that these compounds can be used for fluorimetric monitoring of small pH changes.

Synthesis and antibacterial activities of some schiff bases

Schiff bases p-hydroxybenzylidene-2-carboxyaniline, p-nitrobenzylidene-2- carboxyaniline, p-(N, N-dimethyl)aminobenzylidene-2-carboxyaniline, N-(4-hydroxybezylidene)-benzene-1,2-diamine, N-(4-nitrobezylidene)benzene-1,2- diamine,N-(4-(N, N-dimethylaminobezylidene)benzene-1,2-diamine, N-(4-(N,Ndimethylamino) benzylidene)naphthalen-1-amine,N-(4-nitrobenzylidene) naphthalen-1-amine,N-(4-chlorobenzylidene)naphthalen-1-amine,sodium-4-(4-(N, N-dimethyl amino)benzylideneamino)naphthalene-1-sulfonate,sodium -4-(4-nitrobenzylideneamino) naphthalene-1-sulfonate and sodium-4-(4- chlorobenzylideneamino) naphthalene-1-sulfonate obtained by condensation of aniline and naphthylamine derivatives with some aromatic aldehydes were characterized by physical and spectral methods. The biological activity of these products were as antibacterial agents against three species of human pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Klebsiella sp. Nearly 50% of these compounds showed reasonable activity against the bacterial species investigated and we found that the antibacterial activity is dependent on the molecular structure of the compounds.

Synthesis, characterization and biological activity of some novel formazan derivatives

1-Substituted phenyl-3-substituted phenyl-4-(o-carboxyphenyl) formazans [3a-s] were synthesized by treating azomethines (A1-5) with diazonium salts. Compounds (A1-5) were synthesized by condensing anthranilic acid with various substituted aromatic aldehydes. All the synthesized compounds were characterized by IR, 1H NMR, Mass and elemental analysis and then evaluated for analgesic, antiinflammatory, antibacterial and antifungal activities.

Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents

Diazotization of N-benzylidene anthranilic acids 1a-1n at pH 9 yielded N-[α-(phenylazo) benzylidene] anthranilic acids 2a-2n and at pH 3 yielded N-benzylidene-5-(phenylazo) anthranilic acids 3a-3n. When compounds 3a-3n were treated with thioglycolic/thiolactic acid in the presence of anhydrous ZnCl 2, 2-(4-oxo-2-phenylthiazolidin-3-yl)-5-(phenylazo) benzoic acids 4a-4n were afforded. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities and were compared with standard drugs, aspirin and phenylbutazone. Out of the compounds studied, the most active compound 4n showed more potent activity than the standard drugs at all doses tested.

Synthesis of 2-(o-Arylideneaminophenyl)-3-(5-alkyl-1,3,4-thiadiazol-2-yl)quinazolin-4-ones as Potential Anthelmintic Agents

A series of 2-(o-arylideneaminophenyl)-3-(5-alkyl-1,3,4-thiadiazol-2-yl)quinazolin-4-ones (13-41) have been synthesised and screened for their cestodicidal activity against Hymenolepis nana infection in rats.Compound 19 has been found to be the most active member of the series showing 77.2percent clearance of infection at a dose of 250 mg/kg given for 3 days.

The Role of Carboxyl Group of Anthranilic Acid on the Spectral Properties of its Schiff Bases and Acidity Constants of these Bases

The role of the carboxyl group of anthranilic acid on the spectral properties of its Schiff bases with aromatic aldehydes is elucidated.Band assignment for the different absorption bands observed in the spectra of these Schiff bases is made in the light of solvent polarity, molecular structure and spectral shifts observed in buffer solutions of varying pH's.Furthermore the possible pK values of these Schiff bases were determined and discussed in terms of molecular structure.