42032-51-9

Upstream product

• 288-32-4 1H-imidazole 
• 91-13-4 α,α'-dibromo-o-xylene 
• 89-92-9 2-methylbenzyl bromide 
• 612-12-4 o-Xylylene dichloride 

Downstream Products

• 847359-62-0 [Zn(HPO₄)(1,2-bis(imidazol-1-ylmethyl)benzene)]*H₂O 

Relevant academic research and scientific papers

Synthesis of Imidazolium Oligomers with Planar and Stereo Cores and Their Antimicrobial Applications

A series of imidazolium oligomers with novel planar and stereo core structures were designed and synthesized. These compounds have symmetric structures with different cores, tails, and linkers. These new imidazolium oligomers demonstrated a desirable set

Pyridinophanes as two-centre phase-transfer catalyst for N-alkylation reaction

The synthetic utility of water-soluble pyridinophanes 1 and 2 as an efficient two-centre phase-transfer catalyst for N-alkylation of indoles, imidazole, benzimidazole and benzotriazole has been explored. Application of such pyridinophanes for the synthesis of various precyclophanes involving bis-N alkylation is also described. Georg Thieme Verlag Stuttgart.

IMIDAZOLIUM-QUATERNARY AMMONIUM COPOLYMERS AS NOVEL ANTIBACTERIAL AND ANTIFUNGAL MATERIALS

The present invention relates to quaternary ammonium-imidazolium copolymers having the following Formula (I): where the various groups are as defined in the specification. The present invention also relates to the polymer having the following Formula (II)

IMIDAZOLIUM COMPOUNDS, METHODS OF SYNTHESIS AND USES THEREOF

The present invention generally relates to a non-linear imidazolium compound of Formula (I), comprising a planar or stereo core structure. In addition, the present invention relates to the method of preparing the imidazolium compound as disclosed herein.

Copper(II)-benzotriazole coordination compounds in click chemistry: a diagnostic reactivity study

This diagnostic study aims to shed light on the catalytic activity of a library of Cu(ii) based coordination compounds with benzotriazole-based ligands. We report herein the synthesis and characterization of five new coordination compounds formulated as [CuII(L4)(MeCN)2(CF3SO3)2] (1), [CuII(L5)2(CF3SO3)2] (2), [CuII(L6)2(MeCN)(CF3SO3)]·(CF3SO3) (3), [CuII(L6)2(H2O)(CF3SO3)]·(CF3SO3)·2(Me2CO) (4), and [CuI4(L1)2(L1′)2(CF3SO3)2]2·4(CF3SO3)·8(Me2CO) (5), derived from similar nitrogen-based ligands. The homogeneous catalytic activity of these compounds along with our previously reported coordination compounds (6-13), derived from similar ligands, is tested against the well-known Cu(i)-catalysed azide-alkyne cycloaddition reaction. The optimal catalyst [CuII(L1)2(CF3SO3)2] (10) activates the reaction to afford 1,4-disubstituted 1,2,3-triazoles with yields up to 98% and without requiring a reducing agent. Various control experiments are performed to optimize the method and examine parameters such as ligand variation, metal coordination geometry and environment, in order to elucidate the behaviour of the catalytic system.

ANTIMICROBIAL IMIDAZOLIUM COMPOUNDS

The present invention relates to antimicrobial imidazolium compounds having the structure of Formula (I) wherein R is an optionally substituted aliphatic group that is linear, cyclic, saturated, unsaturated or any combination thereof; n is an integer of a

ZINC COMPLEX

A zinc complex characterized in exhibiting an octahedral structure and being configured from repeating units represented by general formula (I): wherein L represents a linker region, and R1 represents a C1-4 alkyl group, which can have a halogen atom.

An Antifungal Compound

There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.

AN ANTIMICROBIAL COMPOSITION

The present disclosure relates to an antimicrobial composition comprising at least one polymer or oligomer, the polymer and oligomer being comprised of repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer the antimicrobial activity to the composition, methods of producing the same and uses of the antimicrobial composition.

Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and in vitro anticancer studies

A series of N-allyl substituted xylyl-linked imidazolium salts (7-10) and their respective Ag(I)-N-heterocyclic carbene (NHC) complexes (11-14) have been synthesized and characterized by a number of spectral and analytical techniques. Molecular structure of complexes 13 and 14 were established by single-crystal X-ray diffraction method. The in vitro anticancer activity of all imidazolium salts and their Ag(I)-carbene complexes were investigated using human colorectal (HCT 116) cancer cell lines. Imidazolium salts displayed no activity for HCT 116 cell lines, except for 9; yielding IC50 value of 15.9 μM. Ag(I)-carbene complexes 12-14 showed exceptionally good activity (0.9-1.3 μM) against tested cancer cell lines. Furthermore, complex 11 displayed relatively good anticancer activity with IC50 value of 5.2 μM, which is almost equal to standard used.