42053-26-9

Usage

Uses

1. Used in Chemical Synthesis:
DIETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE is used as a reagent for the efficient phosphorylative conversion of alcohols into their corresponding diethyl phosphorotriesters. This conversion is essential in the synthesis of various chemical compounds, particularly in the field of organic chemistry.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, DIETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE is used as a reagent for the synthesis of pharmaceutical compounds that require phosphorylated alcohol groups. Its efficient conversion process aids in the development of new drugs and therapeutic agents.
3. Used in Research and Development:
DIETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE is also utilized in research and development laboratories for studying the properties and reactions of alcohols and their phosphorylated derivatives. This helps in understanding the underlying chemical mechanisms and contributes to the advancement of scientific knowledge in the field of chemistry.

InChI:InChI=1/C10H24NO2P/c1-7-12-14(13-8-2)11(9(3)4)10(5)6/h9-10H,7-8H2,1-6H3

Upstream product

• 589-57-1 diethyl phosphorylchloridite 
• 108-18-9 diisopropylamine 
• 64-17-5 ethanol 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 

Downstream Products

• 140848-39-1 C₁₆H₂₆NO₃P 
• 1569310-55-9 Ac-YVR(phosphorylated threonine)PPK(phosphorylated serine)P(phosphorylated serine)S-NH₂ 
• 1569310-45-7 Ac-GYS(phosphorylated serine)PG(phosphorylated serine)PG(phosphorylated threonine)PGSR-NH₂ 
• 1569310-50-4 Ac-YR(phosphorylated threonine)P(phosphorylated serine)LP(phosphorylated threonine)PP-NH₂ 
• 1569311-36-9 Ac-GPP(phosphorylated threonine)PPGY-NH₂ 
• 1569311-34-7 Ac-GPK(phosphorylated threonine)PPGY-NH₂ 
• 140848-44-8 C₁₆H₂₄N₃O₃P 
• 140848-50-6 ((2S,3S)-2-Ethoxy-1-isopropyl-4,4-dimethyl-2-oxo-2λ⁵-[1,2]azaphosphetidin-3-yl)-phenyl-methanone 

Relevant academic research and scientific papers

Phosphoric acid phaseomannite class compound and its preparation method and application (by machine translation)

The invention discloses a phaseomannite class phosphate compound, phosphoric acid phaseomannite class compound preparation method, and these phosphoric acid phaseomannite class compounds in the preparation of an anti-tumor drug. The use of non-small cell lung cancer cells to the compounds of this invention to inhibit the growth of tumor cells in active testing, that the compounds of this invention have high inhibition of tumor cell growth activity, some of the compound inhibiting activity even with cisplatin active quite, which indicates that the compounds of this invention have good cell penetrability and phosphorus esterase stability, can be used for the development of anti-tumor medicament. (by machine translation)

The study of phosphoramidite as O-phosphitylation agent and its reactivity

O-phosphorylated peptide and amino acid are important in living system. In this paper, Dialkyl-N,N-dialkyl phosphoramidites (DDPA) 3 were synthesized using two methods. The reaction of DDPA with the hydroxyl group of the corresponding amino acids in the presence of tetrazole, followed by oxidation, gave O-phosphoryl amino acid methyl esters in a good yield. A systematical study of the reactivity of DDPA was presented too.

Synthesis of 1,2-Azaphosphetidines

Photolytic or rhodium catalysed decomposition of α-diazo-β-ketophosphonamidates and intramolecular C-H insertion of the resulting carbene intermediates is the key step in the synthesis of mono and bicyclic 1,2-azaphosphetidines.