42056-67-7

Upstream product

• 4651-78-9 2-bromo-1-phenylethylidenemalononitrile 
• 103-85-5 monophenylthiourea 
• 103-72-0 phenyl isothiocyanate 
• 70-11-1 α-bromoacetophenone 
• 103061-74-1 2-(4-Phenyl-2-phenylamino-4,5-dihydro-thiazol-4-yl)-malononitrile; hydrobromide 

Downstream Products

• 98626-89-2 N-phenyl-N-(4-phenyl-thiazol-2-yl)-acetamide 
• 100954-39-0 5-bromo-N,4-diphenylthiazol-2-amine 

Relevant academic research and scientific papers

Convenient one-pot formation of highly functionalized 5-bromo-2-aminothiazoles, potential endocannabinoid hydrolase MAGL inhibitors

Highly functionalized 5-bromo-2-amino-1,3-thiazoles bearing various substituents could be easily prepared by a rapid and efficient one-pot method, using simple starting materials and mild conditions while avoiding the use of metal catalysts or inconvenient reagents such as elemental halogens. These useful products can serve as starting materials for other reactions or as pharmacologically interesting compounds. In our work we have shown that the resulting 5-bromothiazole compounds could lead to monoacylglycerol lipase (MAGL) inhibition in the μM range.

2-ARYLIMINO-3-THIAZOLINES - FORMATION OF UNUSUAL TAUTOMERS OF 2-ARYLAMINOTHIAZOLES BY A MODIFIED HANTZSCH SYNTHESIS

The reaction of thioureas with 3-bromomethyl-2-cyanocinnamonitrile gives the hydrobromides either of the 2-aminothiazoles or of the hitherto unknown 2-imino-3-thiazolines.

2-ARYLIMINO-3-THIAZOLINES - FORMATION OF UNUSUAL TAUTOMERS OF 2-ARYLAMINO-THIAZOLINES - A REVISION

In contrast to previously reported results the products formed in the reaction of arylthioureas with 3-bromomethyl-2-cyanocinnamonitrile are not 2-arylimino-3-thiazolines but 2-arylamino-4-dicyanomethyl-2-thiazolines.