42056-76-8Relevant academic research and scientific papers
Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation
Ramesh, Gondru,Janardhan, Banothu,Rajitha, Bavantula
, p. 8099 - 8109 (2015/04/16)
An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10-60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.
Microwave-assisted synthesis of 2-substituted 4-biarylyl-1,3-thiazoles by carbon-carbon cross-coupling in water
Dawood, Kamal M.,El-Deftar, Moteaa M.
experimental part, p. 1030 - 1038 (2010/06/16)
Suzuki-Miyaura and Heck-Mizoroki C-C cross-coupling reactions of 4-(halophenyl)-1,3-thiazoles with aryl(hetaryl)boronic acids or olefins, respectively, were investigated by using a catalytically active benzimidazole-based palladium(II) complex under both thermal and microwave heating conditions in water. The factors affecting the optimization of such reactions were evaluated.
