4206-16-0

Upstream product

• 64-17-5 ethanol 
• 151-50-8 potassium cyanide 
• 4206-19-3 trans-3-Brom-3',4'-dimethoxy-6-methylflavanon 
• 4406-05-7 2'-Hydroxy-3.4-dimethoxy-5'-methyl-chalkon 
• 106-44-5 p-cresol 
• 39856-08-1 3,4-dimethoxy-cinnamoyl chloride 
• 105166-62-9 6-methyl-3',4'-dimethoxyflavanone 
• 4406-05-7 (E)-2'-hydroxy-3,4-dimethoxy-5'-methylchalcone 
• 105166-59-4 2-Hydroxy-benzoic acid [2-(3,4-dimethoxy-phenyl)-6-methyl-chroman-(4E)-ylidene]-hydrazide 
• 1657006-75-1 C₂₁H₂₂Br₂O₄ 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 

Relevant academic research and scientific papers

A novel one-pot synthesis of flavones

In this paper, a one-pot facile route for the BiCl3/RuCl3-mediated synthesis of functionalized flavones is described, including: (i) intermolecularortho-acylation of substituted phenols with cinnamoyl chlorides, and (ii) intramolecular cyclodehydrogenation of the resultingo-hydroxychalcones. The reaction conditions are discussed herein.

Iodine catalyzed cascade synthesis of flavone derivatives from 2'-allyloxy-α,β-dibromochalcones

Synthesis of flavones from 2'-allyloxy-α, β-dibromochalcones has been described. The iodine induced oxidative cyclization of 2'-allyloxy-α, β-dibromochalcones results into the formation of 3-bromoflavanones which ultimately gives flavones. Dehydrobromination of 3-bromoflavanone to give flavone is the preferred reaction over dehydrogenation.

Synthesis of chromones and pyrazolines as antimicrobial & antifungal agents

A series of chromones and pyrazolines have been synthesized and evaluated for their antimicrobial and antifungal activity against Gram+ve and Gram-ve microorganisms. 2-Hydroxy acetophenone on treatment with substituted aldehydes gave the corresponding cha

Dimethylsulfoxide-iodine catalysed deprotection of 2′- allyloxychalcones: Synthesis of flavones

A new one-pot method is described for the removal of O-allyl protecting groups under oxidative conditions at neutral pH. 2′-Allyloxychalcones undergo deprotection and subsequent oxidative cyclisation to give flavones. The general applicability of the reagent has been studied.

Cyclodehydrogenation of 2'-Hydroxychalcones with Hypervalent Iodine Reagent: A New Synthesis of Flavones

A new synthesis of chrysin (1) and luteolin (4) was accomplished by the cyclodehydrogenation of the appropriately substituted 2'-hydroxychalcones 21 and 22 in the presence of iodosobenzene diacetate/potassium hydroxide in methanol.The scope and limitation of this transformation is discussed. - Keywords: Cyclodehydrogenation / 2'-Hydroxychalcones / Flavones / Iodosobenzene diacetate

SYNTHESIS AND OXIDATION STUDIES OF SOME FLAVANONE N-SALICYLOYL HYDRAZONES WITH SELENIUM DIOXIDE

Some newly synthesized flavanone hydrazones have been oxidized with selenium dioxide in dioxane + water system.The structures of the hydrazones and oxidation products have been established by microelemental analyses, m.m.p., co-TLC and spectral data.

Synthesis and Reaction of 3-Bromoflavanones with DMSO

Bromination of flavanones (I) with (2-carboxyethyl)triphenylphosphonium perbromide gives the corresponding 3-bromoflavanones (II) which when treated with DMSO at room temperature undergo dehydrobromination to flavones (III).