42063-41-2

Basic information

• Product Name: 2-[(2-methoxycarbonylphenylamino)methylene]malonic acid diethyl ester
• Synonyms: 2-[(2-methoxycarbonylphenylamino)methylene]malonic acid diethyl ester
• CAS NO: 42063-41-2
• Molecular Weight: 321.33
• Mol File: 42063-41-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[(2-methoxycarbonylphenylamino)methylene]malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-methoxycarbonylphenylamino)methylene]malonic acid diethyl ester(42063-41-2)
• EPA Substance Registry System: 2-[(2-methoxycarbonylphenylamino)methylene]malonic acid diethyl ester(42063-41-2)

Safety Data

• Hazardous Substances Data: 42063-41-2(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 52693-18-2 2-[(2-carboxy-phenylamino)-methylene]-malonic acid diethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 134-20-3 2-carbomethoxyaniline 
• 1442660-45-8 ethyl 8-benzoyl-4-chloroquinoline-3-carboxylate 
• 455889-15-3 3-ethyl 8-methyl 4-(o-tolylamino)quinoline-3,8-dicarboxylate 
• 1442660-48-1 ethyl 8-benzoyl-4-(o-tolylamino)quinoline-3-carboxylate 
• 170152-22-4 ethyl 8-(4-methylbenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate 
• 170152-21-3 ethyl 8-(4-fluorobenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate 
• 170152-23-5 ethyl 8-(4-chlorobenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate 

Relevant articles and documents

Catalytic formation of ketones from unactivated esters through rhodium chelation-assisted C-O bond activation

A new method for building aryl aryl ketones containing heterocyclic rings through chelation-assisted C-O bond activation catalyzed by a rhodium complex has been developed. In this reaction, methyl quinoline-8-carboxylate, methyl quinoxaline-5-carboxylate, and their derivatives were reacted with an excess amount of a substituted phenyl boronic acid in the presence of a rhodium(I) complex to give substituted phenyl(quinolin-8-yl)methanone, phenylquinoxalin-5- ylmethanone, and their derivatives in medium to high yields. The current method offers a highly favorable synthetic pathway to efficiently build related drugs with an 8-benzoylquinoline core structure. This method may prove especially valuable for medicinal chemists for the late-stage introduction of versatile ketone moieties into complex scaffolds for diversity-oriented synthetic strategies.

Reaction of methyl 2-(2',2'-bis(carbethoxy)vinylamino)benzoate with hydrazine.

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