42065-72-5Relevant academic research and scientific papers
SULFAMIDE DERIVATIVE HAVING AN ADAMANTYL GROUP AND ITS PHARMACEUTICALLY ACCEPTABLE SALT
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Paragraph 0306; 0307; 0329; 0330, (2014/02/16)
Provided is a sulfamide derivative having an adamantyl group represented by the following Formula 1, or a pharmaceutically acceptable salt thereof. The sulfamide derivative suppresses the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and
Synthesis and biological evaluation of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors
Kim, Se Hoan,Bok, Ju Han,Lee, Jae Hong,Kim, Il Hyang,Kwon, Sung Wook,Lee, Gui Bin,Kang, Seung Kyu,Park, Ji Seon,Jung, Won Hoon,Kim, Hee Yeon,Rhee, Sang Dal,Ahn, Sung Hoon,Bae, Myung Ae,Ha, Deok Chan,Kim, Ki Young,Ahn, Jin Hee
supporting information; experimental part, p. 88 - 93 (2012/05/04)
A new series of cyclic sulfamide derivatives were synthesized and evaluated for their ability to inhibit 11β-HSD1. Among this series, 18e showed good in vitro activity toward human 11β-HSD1, selectivity against 11β-HSD2, microsomal stability, and pharmacokinetic and safety profiles (hERG, CYP, and acute toxicity). Additionally, 18e exhibited good in vivo efficacy in rat and monkey models.
COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 68, (2010/07/08)
The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treat
COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 82, (2010/06/19)
The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
INHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 34, (2010/12/29)
The invention relates to the substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 to R13, A, B, L and i are defined as in the description and the claims. The invention also relates to the use thereof in the
COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 40, (2009/03/07)
The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 to R13, A, B, L, and i are defined as indicated in the description and the claims, as well as the use thereof for treating Alzheimer''s disease (AD)
3-AMINOSULFONYL SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF
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Page/Page column 77, (2009/06/27)
The present invention relates to 3-Aminosulfonyl Substituted Indole Derivatives, compositions comprising at least one 3-Aminosulfonyl Substituted Indole Derivative, and methods of using the 3-Aminosulfonyl Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
Substituted 1,2-ethylenediamines, Methods for Preparing Them and Uses Thereof
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Page/Page column 207, (2010/11/24)
The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1-X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
