6276-54-6

Basic information

• Product Name: 1-Amino-3-chloropropane hydrochloride
• Synonyms: 3-AMINOPROPYL CHLORIDE HYDROCHLORIDE;3-CHLORPROPYLAMINE HYDROCHLORIDE;3-CHLOROPROPYLAMINE HCL;3-CHLOROPROPYLAMINE HYDROCHLORIDE;3-chloropropylammonium chloride;1-amino-3-chloropropane hydrochloride;1-Propanamine, 3-chloro-, hydrochloride;3-Chloropropylamine hydrochloride,98%
• CAS NO: 6276-54-6
• Molecular Formula: C₃H₉ClN*Cl
• Molecular Weight: 130.02
• EINECS: 228-474-6
• Product Categories: omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;omega-Haloalkylamines
• Mol File: 6276-54-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 145-150 °C(lit.)
• Boiling Point: 130.7 °C at 760 mmHg
• Flash Point: 32.9 °C
• Appearance: Off-white to yellow-beige/Crystalline Powder or Chunks
• Density: 1.004 g/cm3
• Vapor Pressure: 9.58mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Solubility: DMSO (Slightly), Methanol (Slightly)
• BRN: 3667451
• CAS DataBase Reference: 1-Amino-3-chloropropane hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Amino-3-chloropropane hydrochloride(6276-54-6)
• EPA Substance Registry System: 1-Amino-3-chloropropane hydrochloride(6276-54-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 6276-54-6(Hazardous Substances Data)

Usage

Chemical Properties

off-white to yellow-beige crystalline

Uses

Different sources of media describe the Uses of 6276-54-6 differently. You can refer to the following data:
1. 3-Chloropropylamine hydrochloride was used in chemical treatment of carbon-enriched fly ash concentrates.It was used in the synthesis of linear, star and comb-like polyacrylamides by atomic transfer radical polymerization. It was used in the synthesis of halogen-functionalized aliphatic polyketones (macroinitiators).
2. 3-Chloropropylamine hydrochloride was used in chemical treatment of carbon-enriched fly ash concentrates. It was used in the synthesis of linear, star and comb-like polyacrylamides by atomic transfer radical polymerization. It was used in the synthesis of halogen-functionalized aliphatic polyketones (macroinitiators).

InChI:InChI=1/C3H8ClN/c4-2-1-3-5/h1-3,5H2/p+1

Synthetic route

propan-1-ol-3-amine (156-87-6) → 3-chloropropylamine hydrochloride (6276-54-6)

Conditions	Yield
With thionyl chloride In chloroform at 0℃; Reflux;	93%
With thionyl chloride In chloroform at 0 - 20℃; for 3h; Reflux;	93%
With thionyl chloride In chloroform at 0 - 20℃;

3-hydroxypropylamine hydrochloride → 3-chloropropylamine hydrochloride (6276-54-6)

Conditions	Yield
With thionyl chloride at 25℃; for 1h;	83%

di-tert-butyl dicarbonate (24424-99-5) + 3-chloropropylamine hydrochloride (6276-54-6) → tert-butyl N-(3-chloropropyl)carbamate (116861-31-5)

Conditions	Yield
With sodium hydrogencarbonate; sodium chloride In chloroform; water for 1.5h; Heating;	100%
With triethylamine In dichloromethane at 0 - 25℃; for 21h;	100%
With triethylamine In chloroform Acylation;	95%

3-chloropropylamine hydrochloride (6276-54-6) → 3-azidopropylamine (88192-19-2)

Conditions	Yield
With sodium azide In water at 80℃; for 15h;	100%
With sodium azide In water at 80℃; for 15h;	100%
With sodium azide In water at 80℃; for 15h;	99%

3-chloropropylamine hydrochloride (6276-54-6) + benzaldehyde (100-52-7) → benzylidene-(3-chloro-1-propylamine) (1026774-25-3)

Conditions	Yield
With triethylamine In chloroform at 20℃; for 16h;	100%
With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 1h;	83%
With magnesium sulfate; triethylamine In dichloromethane for 12h;

3-chloropropylamine hydrochloride (6276-54-6) + 4-methoxy-benzaldehyde (123-11-5) → 4-methoxybenzylidene-(3-chloro-1-propylamine)

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: 4-methoxy-benzaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	100%
With triethylamine In chloroform at 20℃; for 16h;	100%
With magnesium sulfate; triethylamine In dichloromethane for 12h;

sulfuryl dichloride (7791-25-5) + 3-chloropropylamine hydrochloride (6276-54-6) → (3-chloropropyl)sulfamyl chloride (42065-72-5)

Conditions	Yield
In acetonitrile at 0 - 85℃;	100%

3-chloropropylamine hydrochloride (6276-54-6) → (3-chloropropyl)sulfamyl chloride (42065-72-5)

Conditions	Yield
With sulfuryl dichloride In acetonitrile at 0 - 85℃;	100%
With sulfuryl dichloride In acetonitrile at 85℃; Cooling with ice;	100%
With sulfuryl dichloride In acetonitrile at 85℃; Cooling with ice;	100%

3-chloropropylamine hydrochloride (6276-54-6) + benzyl chloroformate (501-53-1) → 1-[(benzyloxycarbonyl)amino]-3-chloropropane (53602-19-0)

Conditions	Yield
With sodium hydroxide In water at 0 - 25℃; for 24h;	100%
With sodium hydroxide In water at 0℃; for 12h; Inert atmosphere;	90%
Stage #1: 3-chloropropylamine hydrochloride With sodium hydroxide In water at 0℃; for 0.25h; Schlenk technique; Stage #2: benzyl chloroformate In water at 0℃; for 12h;	2.48 g

C82H125CoN15O15P + 3-chloropropylamine hydrochloride (6276-54-6) → C84H133CoN15O15P

Conditions	Yield
Stage #1: C82H125CoN15O15P With ammonium bromide; zinc In ethanol for 0.333333h; Inert atmosphere; Stage #2: 3-chloropropylamine hydrochloride In ethyl [2]alcohol for 3h; Inert atmosphere;	100%

3-chloropropylamine hydrochloride (6276-54-6) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 3,4-dimethoxybenzylidene-(3-chloro-1-propylamine)

Conditions	Yield
With magnesium sulfate; triethylamine In chloroform at 20℃;	99%

3-chloropropylamine hydrochloride (6276-54-6) + phenyl isothiocyanate (103-72-0) → phenyl(1,3-thiazan-2-yliden)amine (66268-31-3, 133524-17-1, 3420-40-4, 864524-22-1)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h;	99%

3-chloropropylamine hydrochloride (6276-54-6) + p-nitrophenyl isothiocyanate (2131-61-5) → (4-nitrophenyl)(1,3-thiazan-2-yliden)amine

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h;	99%

3-chloropropylamine hydrochloride (6276-54-6) + ortho-anisaldehyde (135-02-4) → 2-methoxybenzylidene-(3-chloro-1-propylamine)

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: ortho-anisaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	99%

methyl o-formylbenzoate (4122-56-9) + 3-chloropropylamine hydrochloride (6276-54-6) → methyl 2-[(3-chloropropylimino)methyl]benzoate (1377966-35-2)

Conditions	Yield
With magnesium sulfate; triethylamine In chloroform at 20℃; for 2h;	99%

3-chloropropylamine hydrochloride (6276-54-6) + 3-Chloropropyltrimethoxysilan (2530-87-2) → C9H22ClNO3Si

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With sodium hydroxide In water for 2h; Cooling with ice; Stage #2: 3-Chloropropyltrimethoxysilan In toluene at 100℃; for 24h; Inert atmosphere;	99%

3-chloropropylamine hydrochloride (6276-54-6) + 3-chloropropylmethyldimethoxysilane (18171-19-2) → C9H22ClNO2Si

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With ammonium hydroxide for 2.5h; Cooling with ice; Stage #2: 3-chloropropylmethyldimethoxysilane In dimethyl sulfoxide at 120℃; for 12h; Inert atmosphere;	99%

chloropropyl(dimethyl)ethoxysilane (13508-63-9) + 3-chloropropylamine hydrochloride (6276-54-6) → C10H24ClNOSi

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With potassium carbonate for 2h; Cooling with ice; Stage #2: chloropropyl(dimethyl)ethoxysilane In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	99%

(3-chloropropyl)triethoxysilane (5089-70-3) + 3-chloropropylamine hydrochloride (6276-54-6) → C12H28ClNO3Si

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With potassium hydroxide for 1h; Cooling with ice; Stage #2: (3-chloropropyl)triethoxysilane In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	99%

N2-atmosphere + 3-chloropropylamine hydrochloride (6276-54-6) + p-Chlorothiophenol (106-54-7) → N-[3-[(4-Chlorophenyl)thio]propyl]amine hydrochloride (78540-43-9)

Conditions	Yield
With sodium ethanolate In ethanol; water	98%

tert-butyldicarbonate (34619-03-9) + 3-chloropropylamine hydrochloride (6276-54-6) → tert-butyl N-(3-chloropropyl)carbamate (116861-31-5)

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	98%
With triethylamine In chloroform at 20℃;	95%

3-chloropropylamine hydrochloride (6276-54-6) + acrylonitrile (107-13-1) → 3-(3-chloro-propylamino)-propionitrile

Conditions	Yield
With sodium In ethanol at 25℃; for 8h;	97%

3-chloropropylamine hydrochloride (6276-54-6) + 3-methoxy-benzaldehyde (591-31-1) → 3-methoxybenzylidene-(3-chloro-1-propylamine)

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: 3-methoxy-benzaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	97%
With magnesium sulfate; triethylamine In dichloromethane for 12h;

4,4'-dimethoxytrityl chloride (40615-36-9) + 3-chloropropylamine hydrochloride (6276-54-6) → 3-chloro-N-4,4'-dimethoxytritylpropanamine (153652-94-9)

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 3h;	96%

Benzophenone oxime (574-66-3) + 3-chloropropylamine hydrochloride (6276-54-6) → O-(3-aminopropyl)benzophenone oxime

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Alkylation;	96%

1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylic acid (865998-76-1) + 3-chloropropylamine hydrochloride (6276-54-6) → N-(3-chloropropyl)-1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxamide

Conditions	Yield
Stage #1: 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylic acid With dmap; HATU In DMF (N,N-dimethyl-formamide) at 20℃; for 0.25h; Stage #2: 3-chloropropylamine hydrochloride With triethylamine In DMF (N,N-dimethyl-formamide)	96%

3-chloropropylamine hydrochloride (6276-54-6) + methyl 4-formylbenzoate (1571-08-0) → 4-methoxycarbonylbenzylidene-(3-chloro-1-propylamine)

Conditions	Yield
With triethylamine In chloroform at 20℃; for 16h;	95%

[CpFe(CO)(CN(CH2)3PPh2)]I (164356-70-1) + 3-chloropropylamine hydrochloride (6276-54-6) → [CpFe(CO)(C(NH(CH2)3Cl)NH(CH2)3PPh2)]I

Conditions	Yield
With NaOCH2CH3 In ethanol; dichloromethane byproducts: NaCl; (inert atm.); addn. of ethanolic soln. of sodium ethylate to soln. of amine hydrochloride deriv. at room temp., stirring for 10 min, filtration,addn. to CH2Cl2 soln. of iron compd. at room temp., stirring overnight; concg., addn. of diethyl ether, filtration, washing with pentane, dryingin vac., elem. anal.;	95%

C18H11ClN2O2 + 3-chloropropylamine hydrochloride (6276-54-6) → N-(3‑chloropropyl)-1-(2-chlorophenyl)-9H-β-carboline-3‑carboxamide

Conditions	Yield
With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran; methanol at 20℃;	95%

3-chloropropylamine hydrochloride (6276-54-6) + isobutyraldehyde (78-84-2) → N-(2-methyl-1-propylidene)-3-chloropropylamine

Conditions	Yield
With magnesium sulfate; triethylamine In dichloromethane for 1h; Ambient temperature;	94%

pyridine-4-carbaldehyde (872-85-5) + 3-chloropropylamine hydrochloride (6276-54-6) → (3-Chloro-propyl)-[1-pyridin-4-yl-meth-(E)-ylidene]-amine

Conditions	Yield
With potassium carbonate In dichloromethane; water for 0.666667h;	94%

3-chloropropylamine hydrochloride (6276-54-6) + 4-bromophenyl isoselenocyanate (147695-56-5) → (4-bromophenyl)(1,3-selenazan-2-yliden)amine

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h;	94%

Upstream product

• 156-87-6 propan-1-ol-3-amine 
• 14302-46-6 3-hydroxypropylamine hydrochloride 

Downstream Products

• 23909-16-2 3-benzylmercaptopropylamine 
• 2799-72-6 3-Chloropropyl isothiocyanate 
• 462-47-5 mercapto-3 propylamine 
• 13286-24-3 S-(3-aminopropyl)thiosulfuric acid 
• 34974-00-0 2-(4-Aminobutyl)pyridine 
• 153652-94-9 3-chloro-N-4,4'-dimethoxytritylpropanamine 
• 16605-03-1 (3-aminopropyl)diphenylphosphine 
• 88192-19-2 3-azidopropylamine 
• 18295-52-8 1-aza-1,3-butadiene 
• 153652-93-8 3-chloro-N-tritylpropanamine 
• 78540-43-9 N-[3-[(4-Chlorophenyl)thio]propyl]amine hydrochloride 
• 96841-76-8 2-mesityl-5,6-dihydro oxazine 
• 166830-87-1 3-(phenyltelluryl)propane-1-amine 
• 166830-96-2 3-aminopropyl(p-methoxyphenyl)telluride 

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