42071-71-6

Basic information

• Product Name: ethyl 2,2-dichloro-3-oxo-3-phenylpropanoate
• Synonyms: ethyl 2,2-dichloro-3-oxo-3-phenylpropanoate
• CAS NO: 42071-71-6
• Molecular Weight: 261.105
• Mol File: 42071-71-6.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2,2-dichloro-3-oxo-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,2-dichloro-3-oxo-3-phenylpropanoate(42071-71-6)
• EPA Substance Registry System: ethyl 2,2-dichloro-3-oxo-3-phenylpropanoate(42071-71-6)

Safety Data

• Hazardous Substances Data: 42071-71-6(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 130478-84-1 2,2-Dichloro-1-phenyl-3-(3,4,5-trimethyl-pyrazol-1-yl)-propane-1,3-dione 
• 64-17-5 ethanol 

Downstream Products

• 54852-70-9 2,2-dichloro-1-phenylpropane-1,3-diol 

Relevant articles and documents

Synthesis of Enantioenriched α,α-Dichloro- and α,α-Difluoro-β-Hydroxy Esters and Amides by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation

A mild and convenient approach was developed to prepare a series of α,α-dihalogeno β-hydroxy esters or amides by using commercially available Noyori's complex [RuCl(p-cymene)(R,R)-TsDPEN] as a catalyst (S/C = 100?200) in the asymmetric transfer hydrogenat

Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one

By the use of 1-chloro-1,2-benziodoxol-3-one, an age-old reagent, the practical and efficient chlorination method is achieved. This hypervalent iodine reagent is amenable not only to the chlorination of nitrogen-containing heterocycles but also to selected classes of arenes, BODIPY dyes, and pharmaceuticals. In addition, the advantages, such as easy preparation and recyclable, air- and moisture-stable, in combination with the success in a gram-scale experiment grant this reagent great potential for industrial application.

Preparation method of 2,2-dihalo-1,3-dicarbonyl derivatives

The invention discloses a method for preparing 2,2-dihalo-1,3-dicarbonyl derivatives. The method is widely applicable to 1,3-dicarbonyl derivatives. The raw materials are easily available, and types are multiple. Types of products obtained by the method are multiple, and the products can be directly used or used in other further reactions. The method has advantages of mild reaction condition, simple reaction operation and post-processing, short reaction time, high yield and little pollution, and is suitable for industrial production.

Iodobenzene dichloride mediated sequential C-Cl bond formation: A safe, convenient and efficient method for the direct α,α-dichlorination of β-dicarbonyl compounds

Various β-keto esters, 1,3-diketones, and β-oxo amides are directly converted into their corresponding α,α-dichloro-β-keto esters, 2,2-dichloro-1,3-diketones, and α,α-dichloro-β-oxo amides, respectively, in moderate to high yields, using iodobenzene dichl

Convenient chlorination with concentrated hydrochloric acid in the presence of iodosylbenzene

An efficient chlorination of -keto esters, 1,3-diketones, and alkenes was performed conveniently with concentrated HCl in the presence of PhIO, selectively giving -chloro - keto esters, 2-chloro-1,3-diketones, and 1,2-dichloroalkanes, respectively. It was suggested that the chlorination took place with (dichloroiodo)benzene generated in situ. A selective anti-addition was observed in the chlorination of indene. Georg Thieme Verlag Stuttgart New York.

Thiourea catalysis of NCS in the synthesis of α-chloroketones

Thiourea catalyzes NCS α-chlorination of alkyl ketones to provide α-chloroketones in very high yields at exceptionally rapid reaction speeds.

A Study on the Reactions of some Ketenes with 1-Aroyl-1H-pyrazoles

1-Aroyl-3,4,5-trimethyl-1H-pyrazoles (1a-c) react with diphenylketene (DPK) to afford the enol esters (2); this was confirmed by X-ray analysis.From the reaction of the pyrazoles (1) with dichloroketene (DCK) the pyrazolylpropanediones (3) are isolated, whereas from the reaction with dimethylketene (DMK) both the enol esters (2) and the pyrazolylpropanediones (3) were obtained.The hydrolysis of the products (3) was also studied.The corresponding pyrazolylpropanediones (10) and the enol esters (11) or their degradation products (12) were isolated from the reactions of the pyrazoles (1a-c) with some mixed anhydrides (9) in the presence of triethylamine.The structure of (10e) has also been confirmed by X-ray crystallography.Plausible schemes accounting for the formation of the products involving as a common step the quaternization of N-1 are envisaged.