42075-27-4

Upstream product

• 626-64-2 pyridin-4-ol 
• 120757-18-8 4-(4-Fluoro-phenyl)-3-methyl-4-oxo-butyric acid methyl ester 
• 81112-09-6 2-chloro-1-(4-fluorophenyl)propan-1-one 
• 462-06-6 fluorobenzene 
• 113118-48-2 ethyl 2-ethoxycarbonyl-3-(4-fluorobenzoyl)butanoate 

Downstream Products

• 113118-49-3 3-<4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl>butanoic acid 
• 112127-66-9 5-methyl-6-[4-(4-oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone 
• 97150-57-7 4,5-dihydro-6-[4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)phenyl]-5-methyl-3(2H)-pyridazinone 
• 116764-34-2 4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid 

Relevant academic research and scientific papers

N-PHENYLPYRIDONE TYPE III PHOSPHODIESTERASES

Phosphodiesterase (type III) inhibitors having the formula: which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals

6-(substituted phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-ones of medicinal interest. The synthesis of SK&F 94836 and SK&F 95654

Two synthetic routes to the dihydropyridazinone-cyanoguanidine 4 (SK&F 94836) are described, both proceeding via the anilino compound 6. An efficient synthesis of the dihydropyridazinone-pyridone 5 (SK&F 95654) is reported. This synthesis proceeds via the fluoro-keto-acid 24, with subsequent displacement of the fluoro substituent by 4-pyridone. The surprising effectiveness of water as a solvent in this reaction has been highlighted.